Dr Richard ten Broek and colleagues estimated the disease burden of the most important complications of postoperative abdominal adhesions, including small bowel obstruction, difficulties at reoperation, infertility, and chronic pain.
The research team performed a systematic review and meta-analyses.
The team searched PubMed, Embase, and Central from 1990 to 2012, without restrictions to publication status or language.
All types of studies reporting on the incidence of adhesion related complications were considered.
The research team's primary outcome was the incidence of adhesive small bowel obstruction in patients with a history of abdominal surgery.
Secondary outcomes were the incidence of small bowel obstruction by any cause, difference in operative time, enterotomy during adhesiolysis, and pregnancy rate after abdominal surgery.
|The incidence of adhesive small bowel obstruction was 2%|
|British Medical Journal|
Subgroup and sensitivity analyses were done to study the robustness of the results.
The team used a random effects model to account for heterogeneity between studies.
The researchers identified 196 eligible papers.
Heterogeneity was considerable for almost all meta-analyses.
The origin of heterogeneity could not be explained by study design, study quality, publication date, anatomical site of operation, or operative technique.
The team noted that the incidence of small bowel obstruction by any cause after abdominal surgery was 9%.
The incidence of adhesive small bowel obstruction was 2%.
The research team found that the presence of adhesions was generally confirmed by emergent reoperation.
In patients with a known cause of small bowel obstruction, adhesions were the single most common cause.
The team observed that operative time was prolonged by 15 minutes in patients with previous surgery.
Use of adhesiolysis resulted in a 6% incidence of iatrogenic bowel injury.
The pregnancy rate after colorectal surgery in patients with inflammatory bowel disease was 50%, which was significantly lower than the pregnancy rate in medically treated patients.
Dr ten Broek's team concludes, "This review provides detailed and systematically analyzed knowledge of the disease burden of adhesions."
"Complications of postoperative adhesion formation are frequent, have a large negative effect on patients’ health, and increase workload in clinical practice."
"The quantitative effects should be interpreted with caution owing to large heterogeneity."