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News

Increased risk of stroke among patients with ulcerative colitis

A study in this month's issue of the International Journal of Colorectal Disease evaluates the risk of subsequent stroke among ulcerative colitis patients.

News image

The risk of venous thromboembolism (VTE) and the development of atherosclerosis are increased in patients with inflammatory bowel disease (IBD).

Ulcerative colitis (UC) is one type of IBD.

However, there is controversy in the literature regarding the association between ulcerative colitis and stroke.

Dr Joseph Keller and colleagues estimated the risk of subsequent stroke among UC patients compared with that among matched comparison subjects drawn from a population-based data set in Taiwan.

The team analyzed administrative claims data sourced from the Taiwan National Health Insurance Database.

The hazard ratio for subsequent stroke among patients with UC was 2.045
International Journal of Colorectal Disease

The researchers evaluated a study cohort comprising 516 UC patients, and a comparison cohort of 2,579 subjects without IBD.

Cox proportional hazards regressions were performed to estimate the risk of subsequent stroke during the follow-up period.

The team also conducted additional analyses investigating the risk of subsequent stroke by age group and gender.

After adjusting for selected medical co-morbidities and recent prescriptions of selected pharmaceuticals, the hazard ratio for subsequent stroke among patients with UC was 2.045 than that among comparison subjects.

While the team did not detect an association between stroke and UC among patients aged 30–40 or 40–50 years, the researchers did detect increased risks for stroke among UC patients aged over 50 years.

The research team also found the association to remain significant for both men and women.

Dr Keller's team comments, "This study detected an increased HR for subsequent stroke among Taiwanese UC patients when compared to that among matched comparison patients without IBD."

Int J Colorectal Dis 2014: 29(7): 805-812
02 July 2014

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