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News

MR vs CT enterography for disease activity in small bowel Crohn's disease

The most recent publication of the Alimentary Pharmacology & Therapeutics compares magnetic resonance enterography with computed tomography enterography for evaluating disease activity in small bowel Crohn's disease.

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Magnetic resonance (MR) enterography has been proposed as a non-ionising alternative method to computed tomography (CT) enterography.

Some studies have directly compared computed tomography enterography and MRE in patients with small bowel Crohn's disease with variable results.

Dr Chen and colleagues from China compared the overall diagnostic accuracy in assessing the activity of small bowel and complications.

MEDLINE, EMBASE and Cochrane databases were searched for studies on the accuracy of magnetic resonance enterography and computed tomography enterography, as compared with a pre-defined reference standard.

Pooled sensitivity, specificity, the weighted area under the curve (AUC), incremental yield and other diagnostic indices were evaluated.
Sensitivity for MR enterography in detecting active small bowel Crohn's disease was 88%
Alimentary Pharmacology & Therapeutics

A total of 290 Crohn's disease patients from 6 different studies were analyzed.

The team found that the pooled sensitivity and specificity for magnetic resonance enterography in detecting active small bowel Crohn's disease was 88%, and 81%, respectively.

The team noted that AUC under the summary receiver-operating characteristic  of magnetic resonance enterography was 0.905.

The researchers observed that the pooled sensitivity and specificity of computed tomography enterography in detecting active small bowel Crohn's disease was 86%, and 84% with the AUC of 0.898.

The AUC of magnetic resonance enterography in detecting fistula, stenosis and abscess was 0.936, 0.931 and 0.996, respectively, compared to 0.963, 0.616 and 0.899 of computed tomography enterography.

The team found no statistically significant incremental yield for magnetic resonance enterography vs. computed tomography enterography.

Dr Chen's team concludes, "Magnetic resonance enterography has a diagnostic effectiveness comparable to computed tomography enterography, thus may serve as a radiation-free alternative for evaluation of patients with Crohn's disease."

Aliment Pharmacol Ther 2014: 40(2): 134–146
25 June 2014

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