Gastroesophageal reflux disease (GERD) is one of the most common diseases affecting patients worldwide, but its risk factors and causes are not clearly known.
Dr Seung-Won Oh and colleagues from Korea investigated the effect of coffee intake on GERD by a meta-analysis.
The research team searched online published research databases such as PubMed, EMBASE, and Cochrane Library for studies that were published up to December 2012.
These publications were reviewed by 2 independent authors, and studies that fulfilled the criteria were selected.
Whenever there was a disagreement between the authors, a consensus was reached by discussion.
|The odds ratio for coffee intake and GERD was 1.06 |
|Diseases of the Esophagus|
The research team identified 15 case–control studies that were included in the final analysis.
The team showed no significant association between coffee intake and GERD.
The team found that the odds ratio was 1.06.
In subgroup analyses in which the groups were subdivided based on the definition of GERD, only the endoscopy group showed a significantly higher odds ratio.
Dr Oh and team conclude, "In subgroup analyses in which the groups were subdivided based on the amount of coffee intake, quality of study, and assessment of exposure, there was no significant association between coffee intake and GERD."