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Helicobacter pylori recurrence after eradiction therapy

This month's publication of Helicobacter investigates Helicobacter pylori recurrence after first- and second-line eradication therapy in Korea.

News image

Recurrence of Helicobacter pylori (H. pylori) infection is the result of either recrudescence or reinfection.

Annual recurrence rates per patient-year of follow-up have been reported to vary across countries.

Dr Sang Woo Lee and colleagues from Korea analyzed recurrence rates of H. pylori after first-line, and second-line eradication therapies in Korea.

From 2007 to 2010, 2691 patients with H. pylori infection received first-line therapy, and 573 patients who failed to respond to first-line therapy received second-line therapy.

H. pylori infection and the success of eradication were assessed by endoscopic biopsy and rapid urease test or 13C-urea breath test.

The eradication rate of the first-line therapy was 80%
Helicobacter

All patients were advised to undergo 13C-urea breath test or esophagogastroduodenoscopy with biopsy or rapid urease test 6 months after eradication, with annual follow-up thereafter.

The research team found that the eradication rate of the first-line therapy was 80%, and that of the second-line therapy was 90% by per protocol analysis.

The researchers noted that the annual recurrence rates sharply declined after 2-year follow-up.

The team found that the annual recurrence rates within and after 2-year follow-up were 9% and 2% after first-line therapy, and those of second-line therapy were 5% and 3%, respectively.

Dr Lee and team commented, "Annual recurrence rates of H. pylori showed a sharp decline after 2-year follow-up after eradication in Korean adults, which is not higher than that of Western countries."

"Enough time interval after treatment is necessary to confirm eradication, and it would not be easy to distinguish between recurrence and recrudescence before 2 years without identifying H. pylori strains."

Helicobacter 2014: 19(3): 202–206
13 June 2014

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