There is emerging debate over the effect of Helicobacter pylori infection on body mass index (BMI).
A recent study demonstrated that individuals who underwent H. pylori eradication developed significant weight gain as compared to subjects with untreated H. pylori colonisation.
Professor Holtmann and colleagues from Australia elucidated the association between H. pylori colonization and the prevalence of overweight and obesity in developed countries.
The literature was searched for publications reporting data on H. pylori prevalence rates, and obesity prevalence rates.
Studies selected reported H. pylori prevalence in random population samples with sample sizes of more than 100 subjects in developed countries.
|The mean H. pylori rate was 44%|
|Alimentary Pharmacology & Therapeutics|
Corresponding BMI distributions for corresponding countries and regions were identified.
Nonparametric tests were used to compare the association between H. pylori and overweight and obesity rates.
The research team identified 49 studies with data from 10 European countries, Japan, the US and Australia.
The mean H. pylori rate was 44%, the mean rates for obesity and overweight were 47% and 14%.
The team noted that the rate of obesity and overweight were inversely and significantly correlated with the prevalence of H. pylori infection.
Professor Holtmann's team concludes, "There is an inverse correlation between H. pylori prevalence and rate of overweight/obesity in countries of the developed world."
"Thus, the gradual decrease of the H. pylori colonization that has been observed in recent decades could be causally related to the obesity endemic observed in the Western world."