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 27 August 2016

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Mortality following hospitalization for ulcerative colitis in Scotland

A study in the latest issue of the Alimentary Pharmacology & Therapeutics compares mortality following hospitalization for ulcerative colitis in Scotland between 19982000 and 20072009.

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Scottish nationwide linkage data from 1998 to 2000 demonstrated high 3-year mortality in patients hospitalised with ulcerative colitis (UC).

Dr Satsangi and colleagues compared 3-year mortality, and factors related to mortality, in Scottish patients hospitalised with UC between 19982000 and 20072009.

The Scottish Morbidity Records and linked datasets were used to assess 3-year mortality, standardized mortality ratio (SMR) and multivariate analyses of factors associated with 3-year mortality.

The 3-year mortality was determined after 4 admission types, including surgery-elective or emergency; medical-elective or emergency.

Age-standardized mortality rates (ASR) were used to compare mortality rates between periods.
Age-standardized mortality decreased from 373 to 264 per 10,000 person-years
Alimentary Pharmacology & Therapeutics

Ulcerative colitis admissions increased from 11 in Period 1 to 12 per 100,000 population per year in Period 2.

Crude and adjusted 3-year mortality fell between time periods.

Adjusted 3-year mortality following emergency medical admission, and in patients >65 years was lower in Period 2.

The team found that the SMR in period 1 was 3.04 and 2.96 in Period 2.

The researchers observed that directly age-standardized mortality decreased from 373 to 264 per 10,000 person-years.

The team noted that increasing age, and co-morbidity were significantly associated with 3-year mortality in Period 2.

Dr Satsangi's team concludes, "Comparisons of crude and adjusted mortality rates suggest significant improvement in outcome over the last decade."

"However, mortality remains high, and older age and co-morbidity are important predictors of outcome."

Aliment Pharmacol Ther 2014: 39(12): 13871397
29 May 2014

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