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Dietary interventions induce histologic remission in eosinophilic esophagitis

The latest issue of Gastroenterology evaluates the efficacy of dietary interventions for inducing histologic remission in patients with eosinophilic esophagitis.

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Various dietary interventions have been used to treat patients with eosinophilic esophagitis (EoE), yielding varied results.

Dr Alfredo Lucendo and colleagues from Spain performed a systematic review to assess the efficacy of different dietary therapies in inducing disease remission.

The researchers performed a systematic search of the MEDLINE, EMBASE, and SCOPUS databases for studies investigating the efficacy of dietary interventions for pediatric and adult patients with EoE.

Summary estimates, including 95% confidence intervals, were calculated for exclusive feeding with amino acid–based elemental formulas, allergy test result–directed food elimination diets, and 6-food elimination diets (SFED).

The team identified 581 references, of which 33 were included in the quantitative summary.

6-food elimination diets were effective for 72% of cases 
Gut

The research team analyzed data on a total of 1317 patients with eosinophilic esophagitis who received different dietary treatments.

Elemental diets were effective for 91% of cases, 6-food elimination diets for 72%, and allergy test result–directed food elimination for 46% of cases.

Additional strategies were also evaluated.

The research team found that adults vs children had no significant differences in remission after dietary interventions.

Dr Lucendo's team concludes, "Dietary interventions are effective in producing histologic remission in patients with eosinophilic esophagitis."

"Elemental diets and 6-food elimination diets were the most effective, achieving <15 eosinophils/high-power field in 91% and 72% of patients, respectively."

Gastroenterology 2014: 146(7): 1639–1648
27 May 2014

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