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Preoperative MELD score as a predictor for posthemihepatectomy complications

A study in the latest issue of the European Journal of Gastroenterology & Hepatology evaluates preoperative predictors of liver hemihepatectomy postoperative complications.

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As diagnostic techniques advance and surgical outcomes improve, the rate of utilization of liver hemihepatectomy for various indications will continue to increase.

Dr Thamer Alghamdi and colleagues explored the preoperative predictors of liver hemihepatectomy postoperative complications.

The team performed a retrospective analysis of the clinical data of patients who underwent either liver hemihepatectomy or extended hemihepatectomy at Georg August University Hospital-Goettingen for the period 2002–2012.

The outcomes were either postoperative complications or death of the patient.

Modified classification of surgical complications was adopted in the current study.

The preoperative model for end-stage liver disease (MELD) score, aspartate aminotransferase, creatinine, international normalized ratio, and bilirubin in addition to the demographic characteristics of the patients and intraoperative blood loss were analyzed as predictive for postliver hemihepatectomy complications.

The study included 144 patients who underwent liver hemiheptectomy or extended hemihepatectomy through the study period.

Postoperative complications were reported among patients out of 52%
European Journal of Gastroenterology & Hepatology

Postoperative complications were reported among patients out of 52%.

The researchers found that the most frequent complications were pleural effusion, biliary leakage, wound dehiscence, ascites, and intra-abdominal abscess.

Death was reported among 6 patients of those who developed complications.

The team observed 4 cases of hepatic cirrhosis.

The research team found that 2 of the microscopic cases had no postoperative complications, whereas 1 case had grade 3a, and the macroscopic case had postoperative complication grade 1.

Their MELD scores ranged between 6 and 10 preoperatively.

The researchers found that the association between preoperative MELD score and development of posthemihepatetomy was statistically significant.

Death was reported in 6 cases, yielding a mortality rate of 4%.

The team observed that MELD score preoperatively was the only significant predictor for postoperative complications.

Dr Alghamdi's team concludes, "The rate of complications following hemihepatectomy remains high, with 52% of the patients in the current study having at least one complication as all of our patients underwent either hemihepatectomy or extended hemihepatectomy."

"A 4% mortality rate has been reported."

"A higher preoperative MELD score is the only significant predictor for the development of posthemihepatectomy complications."

Eur J Gastroenterol Hepatol 2014: 26(6):668-675
26 May 2014

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