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News

Low anterior resection syndrome is associated with quality of life

The quality of life of patients who have had rectal cancer is closely associated with the severity of the low anterior resection syndrome, reports the most recent issue of the Diseases of the Colon & Rectum.

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An increasing number of patients are surviving a diagnosis of rectal cancer.

The majority of the patients are treated with the sphincter-sparing surgical procedure low anterior resection, and 50% to 90% of these patients experience bowel dysfunction, known as the low anterior resection syndrome.

No previous studies have investigated the association between the low anterior resection syndrome and quality of life in an international setting with the use of a validated instrument for the classification of the low anterior resection syndrome.

Dr Therese Juul and colleagues investigated the association between quality of life, and the low anterior resection syndrome in European patients who have had rectal cancer.

The study was designed as an international cross-sectional study involving 5 centers in 4 European countries.

Patients with major low anterior resection syndrome fared worse in all selected subscales
Diseases of the Colon & Rectum

All patients had undergone low anterior resection for rectal cancer, had no stoma, had no dissemination or recurrence at the time of the study, and were at least 16 months past surgery.

The patients received by mail the Low Anterior Resection Syndrome Score and the quality-of-life questionnaire EORTC QLQ-C30.

The team's main outcome measures contained 8 subscales re selected to be the focus of this study, including global quality of life; physical, role, emotional, and social functioning, fatigue, constipation, and diarrhea.

A total of 796 patients were included, which corresponds to a response rate of 75%.

In comparison with patients without low anterior resection syndrome, patients with major low anterior resection syndrome fared substantially worse in all selected subscales, with the exception of constipation.

Dr Juul's team concludes, "The quality of life of patients who have had rectal cancer is closely associated with the severity of the low anterior resection syndrome."

"Therefore, it is important that clinicians and researchers focus on this syndrome to improve the prevention and the treatment of bowel dysfunction and the information given to patients."

Dis Colon Rectum 2014: 57(5): 585–591
02 May 2014

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