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News

Gut microbiota in IBS may have potential influence on therapeutic targets

The latest issue of the Alimentary Pharmacology & Therapeutics evaluates the evidence for the role of gut microbiota in irritable bowel syndrome, and its potential influence on therapeutic targets.

News image

Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disease with a substantial social and economic burden.

Treatment options remain limited and research on the aetiology and pathophysiology of this multifactorial disease is ongoing.

Dr DuPont and colleagues discussed the potential role of gut microbiota in the pathophysiology of IBS, and identified possible interactions with pathophysiologic targets in IBS.

Articles were identified via a PubMed database search [‘irritable bowel syndrome’ AND (anti-bacterial OR antibiotic OR flora OR microbiota OR microflora OR probiotic)].

English-language articles were screened for relevance.

Animal data support the interplay of microbiota with other IBS targets
Alimentary Pharmacology & Therapeutics

Full review of publications for the relevant studies was conducted, including additional publications that were identified from individual article reference lists.

The researcher reported that role of gut microbiota in IBS is supported by varying lines of evidence from animal and human studies.

For example, post-infectious IBS in humans is well documented.

In addition, the researcher found that certain probiotics and nonsystemic antibiotics appear to be efficacious in the treatment of IBS.

Mechanisms involved in improving IBS symptoms likely go beyond mere changes in the composition of the gut microbiota, and accumulating animal data support the interplay of microbiota with other IBS targets, such as the gut–brain axis, visceral hypersensitivity, mucosal inflammation and motility.

Dr DuPont concludes, "The role of the gut microbiota is still being elucidated."

"However, it appears to be one of several important factors that contributes to the etiology and pathophysiology of the irritable bowel syndrome."

Aliment Pharmacol Ther 2014: 39(10): 1033–1042
24 April 2014

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