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High risk of colorectal cancer for carriers of mutations in MUTYH

May's issue of Gastroenterology investigates the risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer. 

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Dr Mark Jenkins and colleagues studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer cases with a MUTYH mutation.

The research team estimated colorectal cancer risks through 70 years of age of 7% for male carriers of monoallelic mutations, and 6% for female carriers of monoallelic mutations, irrespective of family history.

Colorectal cancer risks through 70 years of age were 7% for male carriers of monoallelic mutations

Gastroenterology

The team noted that for monoallelic MUTYH mutation carriers with a first-degree relative with colorectal cancer diagnosed by 50 years of age who does not have the MUTYH mutation, risks of colorectal cancer were 13% for men, and 10% for women.

Dr Jenkins' team commented, "Risks of colorectal cancer for carriers of monoallelic mutations in MUTYH with a first-degree relative with colorectal cancer are sufficiently high to warrant more intensive screening than for the general population."

Gastroenterol 2014: 146(5): 1208-1211.e5
23 April 2014

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