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News

High risk of colorectal cancer for carriers of mutations in MUTYH

May's issue of Gastroenterology investigates the risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer. 

News image

Dr Mark Jenkins and colleagues studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of 264 colorectal cancer cases with a MUTYH mutation.

The research team estimated colorectal cancer risks through 70 years of age of 7% for male carriers of monoallelic mutations, and 6% for female carriers of monoallelic mutations, irrespective of family history.

Colorectal cancer risks through 70 years of age were 7% for male carriers of monoallelic mutations

Gastroenterology

The team noted that for monoallelic MUTYH mutation carriers with a first-degree relative with colorectal cancer diagnosed by 50 years of age who does not have the MUTYH mutation, risks of colorectal cancer were 13% for men, and 10% for women.

Dr Jenkins' team commented, "Risks of colorectal cancer for carriers of monoallelic mutations in MUTYH with a first-degree relative with colorectal cancer are sufficiently high to warrant more intensive screening than for the general population."

Gastroenterol 2014: 146(5): 1208-1211.e5
23 April 2014

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