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Mortality with bleeding Mallory–Weiss syndrome is similar to that of peptic ulcer bleeding.

Mortality in high-risk patients with bleeding Mallory–Weiss syndrome is similar to that of peptic ulcer bleeding, finds this month's issue of the Scandanavian Journal of Gastroenterology.

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Professor Neven LJubičić and colleagues from Croatia identified the predictive factors influencing mortality in patients with bleeding Mallory–Weiss syndrome in comparison with peptic ulcer bleeding.

Between 2005 and 2009, 281 patients with endoscopically confirmed Mallory–Weiss syndrome and 1530 patients with peptic ulcer bleeding were consecutively evaluated.

The 30-day mortality and clinical outcome were related to the patients' demographic data, endoscopic, and clinical characteristics.

The research team found that the one-year cumulative incidence for bleeding Mallory–Weiss syndrome was 7 cases per 100,000 people, and for peptic ulcer bleeding 40 cases per 100,000 people.

Overall 30-day mortality rate was 5% for patients with bleeding Mallory–Weiss syndrome
Scandanavian Journal of Gastroenterology

The age-standardized incidence for both bleeding Mallory–Weiss syndrome and peptic ulcer bleeding remained unchanged during the observational 5-year period.

The team observed that the majority of patients with bleeding Mallory–Weiss syndrome were male patients with significant overall comorbidities.

Overall 30-day mortality rate was 5% for patients with bleeding Mallory–Weiss syndrome, and 4.6% for patients with peptic ulcer bleeding.

The researchers found that in both patients with bleeding Mallory–Weiss syndrome and peptic ulcer bleeding, mortality was significantly higher in patients over 65 years of age and those with significant overall comorbidities.

Professor LJubičić's team concludes, "The incidence of bleeding Mallory–Weiss syndrome and peptic ulcer bleeding has not changed over a 5-year observational period."

"The overall 30-day mortality was almost equal for both bleeding Mallory–Weiss syndrome and peptic ulcer bleeding, and was positively correlated to older age and underlying comorbid illnesses."

Scand J Gastroenterol 2014: 49(4): 458-464
16 April 2014

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