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Mortality and causes of death in Crohn's disease

A study in the latest issue of Gut investigates long-term mortality and causes of death in Crohn's disease.

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Population-based studies have shown a slightly decreased life expectancy in patients with Crohn's disease (CD).

Dr Řistein Hovde and colleagues from Norway evaluated mortality and causes of death 20 years after the diagnosis in a well defined population-based cohort of Crohn's disease patients in Norway.

The Inflammatory Bowel South-Eastern Norway study has prospectively followed all patients diagnosed with Crohn's disease in the period between 1990 and 1993 in 4 geographically well-defined areas.

All patients were age and sex matched with 25 persons from the same county selected at random from the general population.

There were no marked differences in deaths in the Crohn's disease group vs controls 
Gut

The research team collected data on death and causes of deaths from the Norwegian Causes of Death Register.

All causes and cause-specific mortality (gastrointestinal cancer, cancer and heart disease) were modelled with Cox regression model stratified by matched sets. Results are expressed as HRs with 95% CIs.

The team found no significant difference between Crohn's disease patients and controls in overall mortality.

Furthermore, there were no marked differences in deaths from gastrointestinal cancer, other cancers or cardiovascular diseases in the Crohn's disease group compared with the controls.

In the Crohn's disease group, the team observed that 14% had died compared with 13% in the control group.

Dr Hovde's team concludes, "In our population-based inception cohort followed for 20 years, there was no increased mortality or more deaths from cancer compared with the general population."

Gut 2014;63:771-775
10 April 2014

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