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PET-CT as a predictor of outcome in resectable colorectal liver metastases

A study in the latest issue of the European Journal of Gastroenterology & Hepatology identifies predictors of outcomes in resectable colorectal liver metastases.

News image

PET-computed tomography (PET-CT) is a useful staging imaging modality in colorectal liver metastases (CRLM).

Dr Claire Jones and colleagues determine whether PET-CT parameters, standardized uptake value (SUV) and reconstructed tumor volume (RTV), are predictors of prognosis and survival.

A study of all resectable CRLM patients in the regional HPB unit from 2007–2009 was performed.

Preoperative PET-CT scans were retrospectively reviewed.

The team recorded SUV, diameter and RTV for each lesion.

The research team performed correlation analysis with other pathological and biochemical parameters, by Pearson’s correlation analysis.

Reconstructed tumor volume strongly correlated with preoperative CEA
European Journal of Gastroenterology & Hepatology

Survival analysis was performed using Cox regression hazard model.

The team evaluated a total of 79 patients.

SUV moderately correlated with tumor diameter, both PET-CT, and histology, RTV, preoperative carcinoembryonic antigen (CEA), and postoperative CEA.

The researchers found that an independent predictor of SUVmax was preoperative CEA.

RTV strongly correlated with preoperative CEA.

The team observed that SUV and RTV had a negative effect on survival.

Dr Jones' team commented, "PET-CT, in the setting of CRLM, may have a prognostic role in assessing survival."

"Although no definite conclusions can be drawn regarding the prognostic role of SUV and RTV, it acts to reinforce the need for further prospective studies to validate these findings."

Eur J Gastroenterol Hepatol 2014: 26(4): 466-472
04 April 2014

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