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News

Mortality and cancer risk in chronic pancreatitis

This month's issue of Gastroenterology evaluates risk of mortality, cancer, and comorbidities associated with chronic pancreatitis.

News image

Dr Ulrich Christian Bang and colleagues from Denmark assessed the risk of death, cancer, and comorbidities among patients with alcoholic and nonalcoholic chronic pancreatitis.

The research team performed a nationwide retrospective cohort study, collecting data from Danish registries from 1995 through 2010.

The team evaluated the prevalences and incidences of death, cancers, and comorbidities among subjects with chronic pancreatitis (cases) compared with age- and sex-matched individuals (controls).

In total, 11,972 cases and 119,720 controls were included in the analysis.

Cancer was a frequent cause of death among cases, with a hazard ratio of 6.9
Gastroenterology

Hazard ratios were estimated by Cox proportional hazards regression.

The team observed that 46% of the cases died during the follow-up period, compared with 13% of controls, corresponding to a HR of 5.0 for chronic pancreatitis.

Cancer was a frequent cause of death among cases, with a hazard ratio of 6.9.

Alcoholic chronic pancreatitis did not produce a higher risk for cancer or death than nonalcoholic chronica pancreatitis.

The researchers found that cerebrovascular disease, chronic pulmonary disease, ulcer disease, diabetes, and chronic renal disease occurred more frequently among patients with chronic pancreatitis, but myocardial infarction did not.

Dr Bang's team concludes, "Based on a Danish nationwide cohort study, individuals with chronic pancreatitis are at higher risk for death from cancer, and have a higher incidence of comorbidities than people without chronic pancreatitis.

Gastroenterol 2014: 146(4): 989-994.e1
03 April 2014

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