Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 25 August 2016

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Missed or interval colorectal cancer and patient survival

The latest issue of Gastroenterology investigates characteristics of missed or interval colorectal cancer and patient survival.

News image

Colorectal cancers diagnosed within a few years after an index colonoscopy can arise from missed lesions or the development of a new tumor.

Dr Jewel Samadder and colleagues from Utah, USA investigated the proportion, characteristics, and factors that predict interval colorectal cancers that develop within 660 months of colonoscopy.

The research team performed a population-based cohort study of Utah residents who underwent colonoscopy examinations from 1995 through 2009 at Intermountain Healthcare or the University of Utah Health System, which provide care to more than 85% of state residents.

Colonoscopy results were linked with cancer histories from the Utah Population Database to identify patients who underwent colonoscopy 660 months before a diagnosis of colorectal cancer (interval cancer).

Logistic regression was performed to identify risk factors associated with interval cancers.

6% of all patients with colorectal cancer had interval cancers
Gastroenterology

Of 126,851 patients who underwent colonoscopies, 2659 were diagnosed with colorectal cancer.

The research team found that 6% of these colorectal cancers developed within 6 to 60 months of a colonoscopy.

The team observed that sex and age were not associated with interval colorectal cancers.

A higher percentage of patients with interval colorectal cancer were found to have adenomas at their index colonoscopy, compared with patients found to have colorectal cancer detected at colonoscopy or patients who did not develop cancer.

Interval colorectal cancer tended to be earlier-stage tumors than those detected at index colonoscopy, and to be proximally located.

The researchers found that patients with interval colorectal cancer were more likely to have a family history of colorectal cancer, and had a lower risk of death than patients found to have colorectal cancer at their index colonoscopy.

Dr Samadder and concluded, "In a population-based study in Utah, 6% of all patients with colorectal cancer had interval cancers."

"Interval colorectal cancers were associated with the proximal colon, earlier-stage cancer, lower risk of death, higher rate of adenoma, and family history of colorectal cancer."

"These findings indicate that interval colorectal tumors may arise as the result of distinct biologic features and/or suboptimal management of polyps at colonoscopy."

Gastroenterol 2014: 146(4): 950-960
02 April 2014

Go to top of page Email this page Email this page to a colleague

 25 August 2016 
Short-chain fatty acids in mixed refractory constipation
 25 August 2016 
Stool DNA test for colorectal cancer screening
 25 August 2016 
Post-infectious IBS in C. diff
 24 August 2016 
Hep B after infant vaccination program
 24 August 2016 
Obeticholic acid for primary biliary cholangitis
 24 August 2016 
Genetics and therapy response in IBD
 23 August 2016 
Colorectal cancer genetics as biomarkers
 23 August 2016 
Prognostic test for mortality after liver transplant
 23 August 2016 
Postoperative mortality in elderly with IBD
 22 August 2016 
Celiac disease in the elderly
 22 August 2016 
Laparoscopic vs open colectomy databases
 22 August 2016 
Mucosal healing and ulcerative colitis outcomes
 19 August 2016 
Dietary questionnaire for GI clinics
 19 August 2016 
Botox treatment for chronic anal fissure
 19 August 2016 
Myeloid-derived suppressor cells in GI cancers
 18 August 2016 
Gallstone formation determinants
 18 August 2016 
Age disparities in IBD therapy
 18 August 2016 
Seasonal variation in diverticulitis
 17 August 2016 
IBD activity score for routine clinical use
 17 August 2016 
Attitudes to H. pylori in primary care
 17 August 2016 
Nonselective β-blockers and mortality in cirrhosis
 16 August 2016 
Upper GI lesions in adults with IBD
 16 August 2016 
C. difficile infection and mortality when managed by GI surgeons
 16 August 2016 
HCV eradication in cirrhosis
 15 August 2016 
Predicting favorable outcomes in IBD
 15 August 2016 
Scoring system predicted microscopic colitis
 15 August 2016 
Mortality in spontaneous bacterial peritonitis
 12 August 2016 
Recurrence of resected gastric cancer
 12 August 2016 
Screening for pancreatic cancer
 12 August 2016 
Index for diagnostic accuracy of Crohn's
 11 August 2016 
Colorectal neoplasm on surveillance colonoscopies
 11 August 2016 
Bowel disease in primary care patients with bowel symptoms
 11 August 2016 
Diagnosis in covert hepatic encephalopathy
 10 August 2016 
Maintenance therapy for children with eosinophilic esophagitis
 10 August 2016 
Moderate alcohol use and insulin action in HCV
 10 August 2016 
Consensus on the management of GERD
 09 August 2016 
Pancreatitis quality of life instrument
 09 August 2016 
Gallstone disease and NAFLD
 09 August 2016 
Steroid dependency and IBD
 08 August 2016 
Venous thromboembolism in celiac disease
 08 August 2016 
C. diff in IBD 
 08 August 2016 
Gut-directed hypnotherapy vs low FODMAP diet in IBS
 05 August 2016 
Therapy for H.pylori treatment
 05 August 2016 
Obesity and the development of NAFLD
 05 August 2016 
Obesity and CVD in celiac disease
 04 August 2016 
Bleeding after endoscopic resection of colorectal lesions
 04 August 2016 
Novel risk factor for post-ERCP pancreatitis
 04 August 2016 
Ondansetron for children with acute gastroenteritis
 03 August 2016 
Post-colonoscopy complications
 03 August 2016 
IVF in women with IBD
 03 August 2016 
Post-operative pancreatic fistulae after pancreatic surgery
 02 August 2016 
H. pylori in children
 02 August 2016 
Gastric cancer in patients with gastric intestinal metaplasia
 02 August 2016 
Behavioral changes and bariatric surgery
 01 August 2016 
Relapse after cessation of oral antiviral treatment in Hep B
 01 August 2016 
Antimicrobial resistance of H. pylori
 01 August 2016 
Colorectal cancers in IBD
 29 July 2016 
Susceptibility loci for gallstone disease
 29 July 2016 
H. pylori clarithromycin resistance in the USA
 29 July 2016 
Tool to diagnose Helicobacter-negative gastritis

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2016 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us