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 12 February 2016

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News

Phenotype and disease course of early-onset pediatric IBD

Phenotype and disease course of early-onset pediatric IBD, reports the latest issue of Inflammatory Bowel Disease.

News image

Early-onset pediatric inflammatory bowel diseases (IBD) seem to be more extensive than those with a later onset.

To test this hypothesis, Dr Marina Aloi and colleagues examined the phenotype and disease course of patients with IBD diagnosis at 0 to 5 years, compared with the ranges 6 to 11 and 12 to 18 years.

Anatomic locations and behaviors were assessed according to Paris classification in 506 consecutive patients, involving 224 Crohn's disease, 245 ulcerative colitis, and 37 IBD-unclassified.

The researchers found that 11% of patients were in the range 0 to 5 years, 39% in 6 to 11 years, and 50% in 12 to 18 years.

62% of the patients in the 0 to 5 years range had pancolonic ulcerative colitis
Inflammatory Bowel Disease

The team found that ulcerative colitis was the most frequent diagnosis in early-onset-IBD, and in 6- to 11-year-old group, whereas Crohn's disease was predominant in older children.

A classification as IBD-unclassified was more common in the range 0 to 5 years compared with the other groups.

Early-onset Crohn's disease showed a more frequent isolated colonic, and upper gastrointestinal involvement than later-onset disease.

The team noted that 62% of the patients in the 0 to 5 years range had pancolonic ulcerative colitis, compared with 38% of 6 to 11 years, and 31% of 12–18 years range.

No statistical difference for family history for IBD was found in the 3-year age groups.

Therapies at the diagnosis were similar for all children.

However, at latest follow-up, a significantly higher proportion of younger children were under steroids compared with older groups.

The researchers observed that surgical risk did not differ according to age.

Dr Aloi's team comments, "Early-onset-IBD exhibits an extensive phenotype and benefit from aggressive treatment strategies, although surgical risk is similar to later-onset disease."

"A family history for IBD is not common in early-onset disease."

Inflamm Bowel Dis 2014: 20(4): 597-605
02 April 2014

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