Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited.
Dr Devendra Amre and colleagues from Canada investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6/ω3, confers susceptibility to Crohn's disease.
|Children susceptible for Crohn's disease were also carriers of specific variants of CYP4F3 and FADS2 genes|
Based on data from 182 children newly diagnosed with Crohn's disease and 250 controls, the research team found that children who consumed a higher dietary ratio of ω6/ω3 were susceptible for Crohn's disease if they were also carriers of specific variants of CYP4F3 and FADS2 genes.
Dr Amre's team comments, "Our findings implicate diet–gene interactions in the pathogenesis of Crohn's disease."