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Fatigue is highly associated with depression in newly diagnosed patients with IBD

April's issue of the Alimentary Pharmacology & Therapeutics finds that fatigue is highly associated with poor health-related quality of life, disability and depression in newly-diagnosed patients with inflammatory bowel disease, independent of disease activity.

News image

Fatigue is common in Crohn's disease and ulcerative colitis.

Data on fatigue in newly diagnosed patients are unavailable.

Dr Sands and colleagues from New York, USA reported prevalence of fatigue in newly diagnosed Crohn's disease and UC patients, and examined its association with health-related quality of life, depression and disability.

The Ocean State Crohn's and Colitis Area Registry (OSCCAR) is a statewide cohort of newly diagnosed inflammatory bowel disease patients in Rhode Island.

Fatigue was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue Scale.

Patients were administered instruments measuring health-related quality of life, overall disability and work impairment, and depression.

The team found that fatigue was prevalent in 26% of 220 subjects.

Fatigue's association with all scores remained highly despite controlling for disease activity
Alimentary Pharmacology & Therapeutics

Short-Form 36 Health Survey mental health component and physical health component, EuroQol-5D valuation of current health state, Inflammatory Bowel Disease Questionnaire and Patient Health Questionnaire depression scale.

The researchers noted that fatigued patients reported more work impairment and activity impairment on the Work Productivity and Activity Impairment Questionnaire.

Fatigue's association with all scores remained highly significant despite controlling for disease activity.

Dr Sands' team concludes, "Fatigue is strongly associated with poor health-related quality of life, disability and depression similarly in Crohn's disease and ulcerative colitis even when controlling for disease activity."

"Fatigue's association with a wide range of patient-reported outcome measures suggests that monitoring fatigue is a simple way to screen for overall disruption in patient life."

Aliment Pharmacol Ther 2014: 39(8): 811–822
26 March 2014

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