The estimated association between Helicobacter pylori and Barrett's esophagus has been heterogenous across previous studies.
In this study, Dr Lori Fischbach and colleagues from Arkansas, USA examined the association between H. pylori and Barrett's esophagus, and identified factors that may explain or modify this association.
The researchers conducted a case–control study in which they used screening colonoscopy controls recruited from primary care clinics as our primary control group in order to minimize selection bias.
|The overall odds ratios for the association between H. pylori and Barrett's esophagus was 0.55|
|American Journal of Gastroenterology|
All participants underwent an esophagogastroduodenoscopy with gastric mapping biopsies.
The research team used logistic regression to obtain odds ratios, and 95% confidence intervals (CIs) to estimate the association between H. pylori and Barrett's esophagus while controlling for confounders.
The team identified 218 cases, and 439 controls.
The overall odds ratios for the association between H. pylori and Barrett's esophagus after controlling for age and white race was 0.55.
The team observed an even stronger inverse association among participants with corpus atrophy or antisecretory drug use ≥1 time per week, and no inverse association in patients without these factors.
Dr Fischbach's team concludes, "The association between H. pylori and a decreased risk for Barrett's esophagus appears to occur in patients with factors that would likely lower gastric acidity."