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News

Online library of patient-reported outcome measures in Gastroenterology

This month's American Journal of Gastroenterology develops an online library of patient-reported outcome measures in Gastroenterology.

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Because gastrointestinal (GI) illnesses can cause physical, emotional, and social distress, patient-reported outcomes are used to guide clinical decision making, conduct research, and seek drug approval.

It is important to develop a mechanism for identifying, categorizing, and evaluating the over 100 GI patient-reported outcomes that exist.

Dr Brennan Spiegel and colleagues from California, USA described a new, National Institutes of Health (NIH)-supported, online patient-reported outcomesclearinghouse—the GI-patient-reported outcomes database.

Using a protocol developed by the NIH Patient-Reported Outcome Measurement Information System (PROMIS®), the team performed a systematic review to identify English-language GI patient-reported outcomes.

The research team abstracted patient-reported outcome items and developed an online searchable item database.

51% did not include patient input in developing the patient-reported outcome
American Journal of Gastroenterology

The team categorized symptoms into content “bins” to evaluate a framework for GI symptom reporting.

Finally, the research team assigned a score for the methodological quality of each patient-reported outcome represented in the published literature.

The researchers reviewed 15,697 titles, from which they identified 126 patient-reported outcomes.

Review of the patient-reported outcomes revealed 8 GI symptom “bins”, including abdominal pain, bloat/gas, diarrhea, constipation, bowel incontinence/soilage, heartburn/reflux, swallowing, and nausea/vomiting.

In addition to these symptoms, the patient-reported outcomes covered 4 psychosocial domains involving behaviors, cognitions, emotions, and psychosocial impact.

The quality scores were generally low.

In addition, 51% did not include patient input in developing the patient-reported outcome, and 41% provided no information on score interpretation.

Dr Spiegel's team comments, "GI patient-reported outcomes cover a wide range of biopsychosocial symptoms."

"Although plentiful, GI patient-reported outcomes are limited by low methodological quality."

Am J Gastroenterol 2014; 109: 234–248
03 March 2014

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