Because gastrointestinal (GI) illnesses can cause physical, emotional, and social distress, patient-reported outcomes are used to guide clinical decision making, conduct research, and seek drug approval.
It is important to develop a mechanism for identifying, categorizing, and evaluating the over 100 GI patient-reported outcomes that exist.
Dr Brennan Spiegel and colleagues from California, USA described a new, National Institutes of Health (NIH)-supported, online patient-reported outcomesclearinghouse—the GI-patient-reported outcomes database.
Using a protocol developed by the NIH Patient-Reported Outcome Measurement Information System (PROMIS®), the team performed a systematic review to identify English-language GI patient-reported outcomes.
The research team abstracted patient-reported outcome items and developed an online searchable item database.
|51% did not include patient input in developing the patient-reported outcome|
|American Journal of Gastroenterology|
The team categorized symptoms into content “bins” to evaluate a framework for GI symptom reporting.
Finally, the research team assigned a score for the methodological quality of each patient-reported outcome represented in the published literature.
The researchers reviewed 15,697 titles, from which they identified 126 patient-reported outcomes.
Review of the patient-reported outcomes revealed 8 GI symptom “bins”, including abdominal pain, bloat/gas, diarrhea, constipation, bowel incontinence/soilage, heartburn/reflux, swallowing, and nausea/vomiting.
In addition to these symptoms, the patient-reported outcomes covered 4 psychosocial domains involving behaviors, cognitions, emotions, and psychosocial impact.
The quality scores were generally low.
In addition, 51% did not include patient input in developing the patient-reported outcome, and 41% provided no information on score interpretation.
Dr Spiegel's team comments, "GI patient-reported outcomes cover a wide range of biopsychosocial symptoms."
"Although plentiful, GI patient-reported outcomes are limited by low methodological quality."