Help
Subscribe


All of GastroHep is now free access! - Click here to register Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Certolizumab pegol concentrations are associated with endoscopic outcomes in Crohn's

A study in the latest issue of the Clinical Gastroenterology & Hepatology evaluates the association between plasma concentrations of certolizumab pegol and endoscopic outcomes of patients with Crohn's disease.

News image

Monitoring plasma concentrations of anti–tumor necrosis factor agents could optimize treatment of patients with Crohn's disease.

In a post hoc analysis of data from a clinical trial, Dr Jean–Frédéric Colombel and colleagues compared the relationship between plasma concentrations of certolizumab pegol and endoscopic and clinical responses and remission with certolizumab pegol therapy in patients with moderate to severe ileocolonic Crohn's disease.

The research team analyzed data from the Endoscopic Mucosal Improvement in Patients with Active Crohn's Disease Treated with certolizumab pegol trial, from 89 adult patients with active endoscopic Crohn's disease.

Patients received subcutaneous certolizumab pegol (400 mg) at weeks 0, 2, and 4 and then every 4 weeks until week 52.

Higher concentrations of certolizumab pegol at week 8 were associated with endoscopic response
Clinical Gastroenterology & Hepatology

Endoscopic evaluations were performed at weeks 0, 10, and 54.

The research team found that blood samples were collected to measure certolizumab pegol plasma concentrations at weeks 8 and 54.

Certolizumab pegol quartiles at weeks 8 and 54 were correlated with endoscopic response and remission at weeks 10 and 54, respectively.

The team noted that higher concentrations of certolizumab pegol at week 8 were associated with endoscopic response, and remission at week 10.

At week 54, the research team found that rates of endoscopic remission correlated with plasma concentrations of certolizumab pegol.

There was a significant inverse relationship between plasma concentrations of certolizumab pegol, and baseline levels of C-reactive protein and body weight.

Dr Colombel's team concludes, "Endoscopic response and remission are associated with higher plasma concentrations of certolizumab pegol in patients with moderate to severe ileocolonic Crohn's disease."

"These results support the need to consider the pharmacokinetics of anti–tumor necrosis factor agents and therapeutic drug monitoring to optimize treatment."

Clin Gastroenterol Hepatol 2014: 12(3): 423-431.e1
26 February 2014

Go to top of page Email this page Email this page to a colleague

 27 March 2015

Advanced search
 27 March 2015 
Screening for fecal incontinence
 27 March 2015 
Deep remission in Crohn's disease
 27 March 2015 
Sexual functioning in IBD
 26 March 2015 
Antimicrobial therapy in cirrhosis with spontaneous bacterial peritonitis
 26 March 2015 
Metformin as a chemopreventive agent for Barrett's
 26 March 2015 
Survival of untreated hepatocellular carcinoma
 25 March 2015 
Genetics and Crohn's disease
 25 March 2015 
Mortality in Barrett’s–related T1 esophageal adenocarcinoma
 25 March 2015 
Cytomegalovirus and IBD
 24 March 2015 
Prevention of colorectal cancer after screening
 24 March 2015 
Functional GI disorders and body mass index
 24 March 2015 
Quality of life in children with fecal incontinence
 23 March 2015 
Fibrosis in NAFLD vs NASH
 23 March 2015 
The unmasking of Whipple's disease
 23 March 2015 
Predicting the quality of colon cancer care
 20 March 2015 
Interventions for eosinophilic esophagitis
 20 March 2015 
Colorectal cancer risk and genetic variants
 20 March 2015 
Screening for Barrett's esophagus
 19 March 2015 
Hypnotherapy for IBS
 19 March 2015 
Poor mental and physical health in HCV
 19 March 2015 
Dedicated care for diverticular disease
 18 March 2015 
Practice guidelines for colorectal polyps
 18 March 2015 
Out-of-hours endoscopy for upper GI bleeding
 18 March 2015 
H. pylori eradication and lipids
 17 March 2015 
H. pylori test-and-treat program and gastric cancer
 17 March 2015 
Adalimumab in Crohn’s disease
 17 March 2015 

Low-dose PPIs and GI bleeding in patients receiving aspirin

 16 March 2015 
Microscopic colitis
 16 March 2015 
Cholestasis of pregnancy with HCV
 16 March 2015 
Hybrid therapy for H. pylori
 13 March 2015 
Medicare patients and payments to gastroenterologists
 13 March 2015 
Appendectomy in ulcerative colitis
 13 March 2015 

Racial disparities in gluten-sensitive problems

 12 March 2015 
Predicting IBD in IBS patients
 12 March 2015 
Patient knowledge of IBS
 12 March 2015 
Nonceliac gluten sensitivity
 11 March 2015 

Prediction of malignant bile duct obstruction

 11 March 2015 
NAFLD–related hepatocellular carcinoma
 11 March 2015 
Assessment of eosinophilic esophagitis
 10 March 2015 
Risk for gastroesophageal reflux symptoms
 10 March 2015 
Poor disease course in pediatric ulcerative colitis
 10 March 2015 
Outcomes in Crohn's therapy
 09 March 2015 
Fibre usage in ulcerative colitis in remission
 09 March 2015 
Gastric Cancer detection during GI endosocopy
 09 March 2015 
Risk of C. difficile upon hospital admission
 06 March 2015 
Second anti-TNF in IBD
 06 March 2015 
Efficacy of Hep E vaccine
 06 March 2015 
Steroid therapy for eosinophilic esophagitis
 05 March 2015 
EPHXI polymorphism and esophageal cancer risk
 05 March 2015 
Infliximab and immunosuppressant therapy in ulcerative colitis
 05 March 2015 
Neuroendocrine carcinoma of the colon and rectum
 04 March 2015 
Multidisciplinary management of rectal cancer
 04 March 2015 
Management of IBD
 04 March 2015 
Progression of Barrett's
 03 March 2015 
EPHX1 polymorphism and esophageal cancer risk
 03 March 2015 
GI bleeding in chronic kidney disease patients on aspirin
 03 March 2015 
Risk of anastomotic leak after colectomy
 02 March 2015 
Genes and early diagnosis of IBD
 02 March 2015 
Assessment of GERD
 02 March 2015 
Liver disease in patients awaiting liver transplant

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2015 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us