Inflammatory bowel disease (IBD) is associated with an increased risk of venous thromboembolic disease.
However, it is unclear whether IBD modifies the risk of arterial thromboembolic events, including cerebrovascular accidents (CVA) and ischemic heart disease (IHD).
Dr Darrell Pardi and colleagues from Minnesota, USA performed a systematic review and meta-analysis of cohort and case-control studies that reported incident cases of CVA and/or IHD in patients with IBD and a non-IBD control population. .
The researchers analyzed data from 9 studies.
IBD was associated with a modest increase in the risk of CVA, especially among women compared with men, and in young patients.
|IBD also was associated with a 19% increase in the risk of IHD|
|Clinical Gastroenterology & Hepatology|
The team observed the increase in risk for patients with Crohn's disease, and in those with ulcerative colitis.
IBD also was associated with a 19% increase in the risk of IHD, both in patients with Crohn's disease and ulcerative colitis.
This risk increase was seen primarily in women compared with men, in young and old patients.
The research team found that IBD was not associated with an increased risk of peripheral arterial thromboembolic events.
Considerable heterogeneity was observed in the overall analysis.
Dr Pardi's team concludes, "IBD is associated with a modest increase in the risk of cardiovascular morbidity (from CVA and IHD)—particularly in women."
"These patients should be counseled routinely on aggressive risk factor modification."