Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 21 June 2018

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Link between measles virus and gut abnormalities in children with developmental disorder

Measles virus may link a new form of inflammatory bowel disease (IBD) and developmental disorder, suggests a study in Journal of Clinical Pathology - Molecular Pathology, to be published in the spring, but released immediately in full on the Internet.

News image

fiogf49gjkf04

The authors (from Dublin, Ireland and London, England) conclude that the virus may act as an immunologic trigger. It was found in the intestinal biopsies of 75 out of 91 children with the variant form of bowel disease (ileocolonic lymphonodular hyperplasia), but in only 5 out of 70 healthy children.

It was found that more boys than girls were affected.

The study does not report whether the children were vaccinated with the triple mumps measles and rubella (MMR) vaccine.

An accompanying editorial advises against jumping to any hasty conclusions about MMR causing either the bowel disease or the developmental disorder, or it being responsible for all cases of autism and/or IBD.

The editorial concludes that there is evidence that developmental disorders are associated with some disturbance in the interaction between the brain and the gut, and that the study findings warrant attention.

Proportion with measles virus:
Bowel disorder: 82%
Controls: 7%
Journal of Clinical Pathology - Molecular Pathology

However, the authors say that several critical questions need to be answered before any potential link with MMR can be proved. These include whether the measles virus was the same strain as that used in the vaccine.

In a statement issued today, Professor John O'Leary, molecular pathologist at Coombe Women's Hospital, Dublin, Ireland, and lead author of the study, comments, "I stand by the findings of our research, which raises many questions about whether measles virus has a role in bowel inflammation in developmental disorder.

"The research did not set out to investigate the role of MMR in the development of either bowel disease or developmental disorder, and no conclusions about such a role could, or should be, drawn from our findings."

The editors of Molecular Pathology, Professor John Crocker and Dr David Burnett, add, "This paper was submitted by a scientist of international reputation, and accepted for publication after peer review.

"It was recognized by the referees and the editors as a potentially important observation which raised many questions about the possible role of measles in the etiology of a syndrome in children.

"The paper did not set out to investigate the role of MMR in developmental disorders or bowel disease, and no role for MMR is suggested in it."

"But we did accept that some readers might jump to the conclusion that this paper does in some way link MMR to behavioral disorders," they said.

"We therefore commissioned a commentary by a member of our editorial board.

"That commentary reinforces our view that this research is an important piece of work that draws conclusions entirely consistent with the data, but that any link with MMR is not justified, and was not intended by the study authors," they concluded.

J Clin Pathol-Mol Pa 2002; 55: 1-6
06 February 2002

Go to top of page Email this page Email this page to a colleague

 31 May 2018 
Diagnostic for NAFLD  
 31 May 2018 
Bile acids and the risks for hepatotoxicity
 31 May 2018 
Rectal cancer female sexuality score
 30 May 2018 
Fungal dysbiosis in cirrhosis
 30 May 2018 
Placebo rates in ulcerative colitis trials
 30 May 2018 
Follow-up testing and colorectal cancer mortality
 29 May 2018 
Organ transplantation donors
 29 May 2018 
Novel therapies for IBD
 29 May 2018 
Helicobacter pylori infection to stomach cancer
 28 May 2018 
Mesalazine in ulcerative colitis
 28 May 2018 
Technology and management of digestive diseases
 28 May 2018 
Therapeutic strategies for HCV
 25 May 2018 
Post‐operative complications in elderly IBD
 25 May 2018 
Technology to increase colorectal cancer screening
 25 May 2018 
Colorectal cancer–specific mortality
 24 May 2018 
Alcohol consumption and outcomes in drug-induced liver injury
 24 May 2018 
Patient-reported outcome measures in IBD trials
 24 May 2018 
Precision medicine for tumors
 23 May 2018 
Management of perianal fistulas in Crohn’s disease
 23 May 2018 
Cardiovascular risk in diabetes mellitus with NAFLD
 23 May 2018 
High body mass index is and ulcerative colitis
 22 May 2018 
Worldwide H.pylori prevalence
 22 May 2018 
PPI and risk of stroke
 22 May 2018 
Online tool predicts bowel dysfunction severity prior to anterior resection
 21 May 2018 
PPI use and cognitive decline
 21 May 2018 
Depressive symptoms in IBD youth
 21 May 2018 
Fecal incontinence and quality of life in IBD
 18 May 2018 
Esophageal dilatation in clinical practice 
 17 May 2018 
IBD and later extraintestinal manifestations
 17 May 2018 
Repeat stool DNA testing
 17 May 2018 
IBS and chronic fatigue following GI infection
 16 May 2018 
Factors associated with fecal incontinence
 16 May 2018 
Diagnostic delay in Crohn's disease
 16 May 2018 
Cardiovascular risk in diabetes mellitus with NAFLD
 15 May 2018 
Guidelines for management of Crohn's
 15 May 2018 
New therapies for CDI
 15 May 2018 
Hep B in the Grey Zone
 14 May 2018 
Blood test for the diagnosis of fibrotic NASH
 14 May 2018 
Outcomes at bariatric centers of excellence
 14 May 2018 
Management of perianal fistulas in Crohn’s
 11 May 2018 
Detection of undiagnosed celiac disease
 11 May 2018 
Alcohol consumption and drug-induced liver injury
 10 May 2018 
Colorectal cancer screening
 10 May 2018 
Fibrosis in patients with chronic hepatitis B
 09 May 2018 
Fecal incontinence
 09 May 2018 
Health problems and IBS
 09 May 2018 
Esophageal dilatation in clinical practice 
 07 May 2018 
Health problems and IBS
 07 May 2018 
Assessment of diminutive colorectal polyps
 07 May 2018 
Omitting antibiotics in uncomplicated acute diverticulitis
 04 May 2018 
National Institutes of Health workshop and obesity
 04 May 2018 
Factors associated with fecal incontinence
 04 May 2018 
Colorectal cancer screening and ethnic inequities
 03 May 2018 
Gastrointestinal ultrasound in IBD
 03 May 2018 
Ultransonography in postsurgical recurrence in Crohn's
 02 May 2018 
Chronic Hep B
 02 May 2018 
Hep C antiviral treatment and liver cancer risk
 02 May 2018 
Symptom assessment in cirrhotic ascites
 01 May 2018 
Interferon‐free regimens in Hep C
 01 May 2018 
European guidelines on pancreatic cystic neoplasms

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2018 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us