A customized screening program for gastric cancer would optimize the benefits of screening endoscopy.
Professor Hwoon-Yong Jung and colleagues from Korea investigated the risk factors for gastric cancer detected during screening and factors affecting clinical outcomes.
From 2000 to 2010, subjects who underwent screening endoscopy at Asan Medical Center were included.
To investigate risk factors, age- and sex-matched control group was selected.
The clinical outcomes of gastric cancer identified during screening were compared with age, sex, and date of diagnosis-matched subjects who were diagnosed with gastric cancer in the outpatient clinic.
Of 109,530 subjects, 327 were diagnosed with gastric cancer.
|5-year survival rate was significantly higher in the screening group |
|Journal of Gastroenterology & Hepatology|
The research team found that the median age of the screening group was 64 years.
When comparing with the control group, the team found that Helicobacter pylori seropositivity, carcinoembryonic antigen, family history of gastric cancer, and drinking were independent positive risk factors, and the use of aspirin a negative risk factor for gastric cancer in multivariate analysis.
The research team noted that low-density lipoprotein cholesterol, cancer antigen 19-9, resectability, and family history were independent risk factors for death.
The researchers observed that the 5-year survival rate was significantly higher in the screening group than in the outpatient group.
Professor Jung's team concluded, "Early detection of gastric cancer by screening endoscopy while asymptomatic enhances patient outcomes, especially in high-risk groups."