The characteristics of peptic ulcer disease (PUD) are changing.
Dr Malmi and colleagues from Finland evaluated time trends in the incidence of peptic ulcer disease, and its complications in hospitalized patients at the beginning of the 21st century, drug therapies in out-patient care as a risk factor for recurrent PUD, and medication used by peptic ulcer disease patients compared with the background population.
The team performed a retrospective epidemiologic cohort study, using data from the years 2000–2008 came from The Hospital District of Helsinki and Uusimaa, and the Finnish Care Register.
All hospitalized adult patients with peptic ulcer disease in the capital region of Finland were included.
The data were linked with nationwide Prescription Register of the Finnish Social Insurance Institution allowing detailed individual medicine purchase data.
A total of 9951 peptic ulcers were detected among 8146 individual patients during the study period.
The research team found that the mean annual incidence of all peptic ulcers decreased from 121/100 000 in 2000–2002, to 79 in 2006–2008.
Decrease in incidence was seen in all age groups and in both sexes.
The research team found that overall rate of severe complications of peptic ulcer disease was reduced.
The team observed that the 1-year cumulative incidence of recurrent ulcers was 13%.
Use of several drugs was associated with increased risk for recurrence.
The purchases of various drugs were more common among peptic ulcer disease patients compared with background population.
Dr Malmi's team commented, "Both the incidence and complication rates have markedly decreased during the study period."
"Recurrent peptic ulcer disease was associated with polypharmacy."