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Endoscopic resection therapies for rectal neuroendocrine tumors

A study in the latest Journal of Gastroenterology & Hepatology compares various endoscopic resection therapies for rectal neuroendocrine tumors.

News image

There are various endoscopic resection therapies, including conventional endoscopic mucosal resection (EMR) only with a snare after submucosal injection, modified EMR (m-EMR) with other assistant devices such as a ligation band or a suction cap, and endoscopic submucosal dissection (ESD).

Mr Wei Fu and colleagues from China evaluated which is the best choice for rectal neuroendocrine tumors.

The research team performed a broad literature research, and a systematic review and meta-analysis were conducted.

The team identified 10 retrospective studies with 650 patients.

Local recurrence occurred in 5 cases in the EMR group
Journal of Gastroenterology & Hepatology

Complete resection rates were significantly higher in the ESD group compared with the EMR group, in the m-EMR group compared with the conventional EMR group, and was comparable between the ESD group and the m-EMR group.

Procedure time was significantly longer in the ESD group than in the EMR group, but there was no significant difference between that of the m-EMR group and ESD group.

The team observed that local recurrence occurred in 5 cases in the EMR group, and did not occur in the ESD group.

Mr Fu's team comments, "ESD or m-EMR techniques could be applied to rectal neuroendocrine tumors with indications for endoscopic treatment."

"m-EMR procedures appear to be comparable with ESD in the treatment of rectal neuroendocrine tumors."

"However, the findings have to be carefully interpreted due to the lower level of evidence."

J Gastroenterol Hepatol 2014: 29(2): 259–268
13 February 2014

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