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Management of chronic Hep C in patients with contraindications to anti-viral therapy

The latest issue of the Alimentary Pharmacology & Therapeutics Management of chronic hepatitis C in patients with contraindications to anti-viral therapy

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There are patients with chronic hepatitis C who are not eligible for the current interferon-based therapies or refuse to be treated due to secondary effects.

Dr Carreño and colleagues provided information on alternative treatments for the management of these patients.

The team performed a PubMed search to identify relevant literature.

Search terms included hepatitis C virus, anti-inflammatory treatment, antioxidant, natural products and alternative treatment, alone or in combination.

Coffee consumption is associated with a biochemical improvement
Alimentary Pharmacology & Therapeutics

Additional publications were identified using the references cited by primary and review articles.

Several approaches, such as iron depletion (phlebotomy), treatment with ursodeoxycholic acid or glycyrrhizin, have anti-inflammatory and/or anti-fibrotic effects.

Life interventions like weight loss, exercise and coffee consumption are associated with a biochemical improvement.

The team found that other alternatives (ribavirin monotherapy, amantadine, silibinin, vitamin supplementation, etc.) do not have any beneficial effect or need to be tested in larger clinical studies.

Dr Carreño's team concludes, "There are therapeutic strategies and lifestyle interventions that can be used to improve liver damage in patients with chronic hepatitis C who cannot receive or refuse interferon-based treatments."

Aliment Pharmacol Ther 2014: 39(2): 148–162
14 January 2014

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