Help
Subscribe


Submit Videos to GastroHep Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Improved survival of gastric cancer with tumor EBV positivity

The most recent issue of Gut examines survival of gastric cancer with Epstein-Barr virus positivity in the tumor cells.

News image

About 9% of gastric carcinomas have Epstein–Barr virus (EBV) in the tumor cells, but it is unclear whether viral presence influences clinical progression.

Dr Constanza Camargo and colleagues from Maryland, USA therefore examined a large multicenter case series for the association of tumor EBV status with survival after gastric cancer diagnosis, accounting for surgical stage and other prognostic factors.

The research team combined individual-level data on 4599 gastric cancer patients diagnosed between 1976 and 2010 from 13 studies in Asia, Europe, and Latin America.

EBV positivity of tumors was assessed by in situ hybridization.

Tumor EBV positivity was 8% overall
Gut

Mortality hazard ratios for EBV positivity were estimated by Cox regression models stratified by study, adjusted for distributions of sex, age, stage, tumor histology, anatomic subsite and year of diagnosis.

Variations by study and continent were assessed using study-specific hazard ratios for EBV positivity.

The team observed that during median 3 years follow-up, 49% of patients died.

Stage was strongly predictive of mortality, with unadjusted hazard ratios of 3 for stage II, 8 for stage III, and 13 for stage IV.

The research team found that tumor EBV positivity was 8% overall, and inversely associated with stage.

Adjusted for stage and other confounders, EBV positivity was associated with lower mortality, with low heterogeneity among the study populations.

The team noted that the association did not significantly vary across patient or tumor characteristics.

The researchers found no significant variation among the 3 continent-specific hazard ratios.

Dr Camargo's team concludes, "Our findings suggest that tumor EBV positivity is an additional prognostic indicator in gastric cancer."

"Further studies are warranted to identify the mechanisms underlying this protective association."

Gut 2014; 63: 236-243
10 January 2014

Go to top of page Email this page Email this page to a colleague

 22 July 2014

Advanced search
 22 July 2014 
Thromboembolism in IBD
 22 July 2014 
Cognitive behavioral therapy in IBS
 22 July 2014 
Alcohol and colorectal adenoma risk
 21 July 2014 
Stents to prevent post-ERCP pancreatitis
 21 July 2014 
Psychometric validation of IBS symptom severity
 21 July 2014 
Mortality in IBD
 18 July 2014 
Treatment of enteropancreatic neuroendocrine tumors
 18 July 2014 
Ulcer complications and dyspeptic symptoms
 18 July 2014 
ERCP with overtube-assisted enteroscopy
 17 July 2014 
Treatment of H. pylori
 17 July 2014 
Ultrasound for diagnosis of gastric varices
 17 July 2014 
Small intestinal permeability in diarrhea predominant IBS
 16 July 2014 
Mortality after colectomy in IBD
 16 July 2014 
Esophageal cancer missed at endoscopy
 16 July 2014 
Screening for Hepatitis B
 15 July 2014 
Diagnosing diverticulitis
 15 July 2014 
Variation in management decisions for colorectal cancer
 15 July 2014 
Muscle cramps in cirrhosis
 14 July 2014 
Predicting the course of ulcerative colitis
 14 July 2014 
Choice in colorectal cancer screening tests
 14 July 2014 
Adhesions in abdominal surgery
 11 July 2014 
Temporal evolution of antidrug antibodies in IBD
 11 July 2014 
Atopy and functional gastrointestinal disorders
 11 July 2014 
Fecal microbiota transplant for C. diff
 10 July 2014 
Acid-suppressive medications and cancer risk in Barrett's
 10 July 2014 
Personalized medicine in the management of IBD
 10 July 2014 
Pregnancy outcome in anti-TNF treated women with IBD
 09 July 2014 
Quality of care provided to patients with varices
 09 July 2014 
Eosinophilic esophagitis and celiac disease
 09 July 2014 
Diagnosis and management of adult celiac disease
 08 July 2014 
NSAID-induced small intestinal injury
 08 July 2014 
Drug-induced liver injury
 08 July 2014 
Screening for Hep B
 07 July 2014 
Obesity and complications after lapaproscopic colorectal surgery
 07 July 2014 
Everolimus and advanced hepatocellular carcinoma
 07 July 2014 
Pediatric celiac disease risk factors
 04 July 2014 
Day-case vs inpatient laparoscopic fundoplication
 04 July 2014 
Alcohol assessment in liver transplant
 04 July 2014 
Clinical competence in colorectal cancer surgery
 03 July 2014 
Predicting acute liver failure in drug-induced liver injury
 03 July 2014 
Cognitive dysfunction impairs quality of life after liver transplant
 03 July 2014 
NOTES for colon resections
 02 July 2014 
Routine colonoscopy for uncomplicated diverticulitis
 02 July 2014 
Risk of stroke in ulcerative colitis
 02 July 2014 
Hemodialysis during liver transplant
 01 July 2014 
Outcomes for pregnant women with primary biliary cirrhosis
 01 July 2014 
Liver-prognosis assessment in Hep C
 01 July 2014 
Mortality from biliary diseases requiring ERCP
 30 June 2014 
Combination therapy for eradication of Helicobacter pylori
 30 June 2014 
Drug-induced liver injury
 30 June 2014 
Surrogate for adenoma detection rate
 27 June 2014 
Infliximab and luminal pediatric Crohn's
 27 June 2014 
Colonoscopy surveillance intervals
 27 June 2014 
Endoscopy protocol for serrated polyposis syndrome
 26 June 2014 
Cognitive impairment in celiac disease
 26 June 2014 

Congenital malformations in offspring of parents with celiac disease

 26 June 2014 
Risk of colorectal adenomas and glucose metabolism
 25 June 2014 
Acceptance of split-dose bowel prepartation for colonoscopy
 25 June 2014 
Preventing gallbladder stones during weight loss
 25 June 2014 
Evaluating disease activity in small bowel Crohn's

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2014 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us