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Food intake increases liver stiffness measurements in chronic hepatitis B

Food intake increases liver stiffness measurements and hampers reliable values in patients with chronic hepatitis B and healthy controls, reports the latest issue of the Alimentary Pharmacology & Therapeutics.

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By increasing the hepatic blood circulation, food intake has been suggested to increase liver stiffness measurement (LSM) values in HCV-infected patients.

Dr Lemoine and colleagues from West Africa investigated prospectively the effects of food intake on LSM in hepatitis B virus (HBV)-infected patients and healthy controls.

In Gambia, patients included in the PROLIFICA project are screened for HBV at the community level, and then invited for fasting assessment including LSM.

During 2012, each day, the first 5 participants were invited to participate in this study.

After the initial examination, a standardized 850 Kcal breakfast was provided.

Effect of food intake was assessed by examining mean difference of LSM, IQR and IQR/LSM at T0 (fasting LSM1), T30min (LSM2) and T120min (LSM3) respectively.

A total of 209 subjects were enrolled in this study.

Food intake can overestimate liver fibrosis
Alimentary Pharmacology & Therapeutics

The team reported that unreliable measurements occurred more frequently after food intake.

In both groups, median LSM2 was significantly higher than LSM1.

The research team found that LSM3 was still higher than the baseline, but lower than LSM2.

In multivariable analysis, the team found that no factor modified the effect of breakfast on LSM.

In a subgroup of patients having liver biopsies, the researchers confirmed that food intake can overestimate liver fibrosis.

Dr Lemoine's team, "Food intake significantly increases liver stiffness measurement and its IQR values in patients with chronic hepatitis B as well as healthy individuals, and also the number of unreliable liver stiffness measurement values."

Aliment Pharmacol Ther 2014: 39(2): 188–196
10 January 2014

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