Help
Subscribe


All of GastroHep is now free access! - Click here to register Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Treatment of Hepatitis B in chronic kidney disease patients

January's issue of the Alimentary Pharmacology & Therapeutics examines the use of nucleos(t)ide analogues in patients with chronic hepatitis B virus infection and chronic kidney disease.

News image

The treatment of chronic hepatitis B in patients with chronic kidney disease (CKD) is based on nucleoside (lamivudine, telbivudine, entecavir) or nucleotide (adefovir, tenofovir) analogues (NAs), but it may be complex and the information is scarce.

Entecavir and tenofovir represent the currently recommended first-line NAs for NA-naive chronic hepatitis B patients, while tenofovir is the NA of choice for chronic hepatitis B patients with resistance to nucleosides.

Dr Papatheodoridis and colleagues from Greece reviewed the efficacy and safety of NAs in adult chronic hepatitis B patients with chronic kidney disease and to provide reasonable recommendations for their optimal management.

The team performed a literature search in PubMed/Medline and manual search of relevant articles, reviews and book chapters.

Psychiatric drug dispensings were more common among female IBD patients
Alimentary Pharmacology & Therapeutics

NAs are cleared by kidneys and their dosage should be adjusted in patients with creatinine clearance <50 mL/min.

The team report concerns about nephrotoxic potential of the nucleotides, particularly adefovir, while improvements of creatinine clearance have been reported under telbivudine.

The researchers noted that most existing data in chronic hepatitis B patients with CKD are for lamivudine and, less frequently, for other NAs, mostly entecavir.

Besides chronic hepatitis B, NA should be used in case of immunosuppressive therapy in any HBsAg-positive patient with CKD including renal transplant (RT) recipients, and in anti-HBs-positive recipients of kidney grafts from HBsAg-positive donors.

Dr Papatheodoridis' team comments, "Chronic hepatitis B patients with chronic kidney disease receiving nucleoside analogues should be followed carefully for treatment efficacy and renal safety."

"Despite the absence of strong data, entecavir and telbivudine seem to be the preferred options for nucleoside analogue-naive chronic hepatitis B patients with chronic kidney disease, depending on viraemia and severity of renal dysfunction."

"More studies are certainly needed in this setting."

Aliment Pharmacol Ther 2014: 39(1): 35-46
11 December 2013

Go to top of page Email this page Email this page to a colleague

 18 April 2014

Advanced search
 18 April 2014 
GastroHep.com Easter break
 17 April 2014 
Diabetes mellitus and acute pancreatitis
 17 April 2014 
Screening for low bone mineral density among ulcerative colitis
 17 April 2014 
Bowel cleansing for colonoscopy
 16 April 2014 
Evaluating pharmacologic agents in IBS
 16 April 2014 
Isotretinoin and IBD risk
 16 April 2014 
Mortality in bleeding Mallory-Weiss syndrome vs peptic ulcer bleeding
 15 April 2014 
Dietary fat and risk of IBD
 15 April 2014 
Quality of life in microscopic colitis
 15 April 2014 
New prognostic score for cirrhosis
 14 April 2014 
Changing liver cancer mortality rates in the United States
 14 April 2014 
Inflammatory sacroiliitis by MRI in IBD
 14 April 2014 

5-aminosalicylates in early pregnancy and congenital malformation risk

 11 April 2014 
H pylori resistance to antibiotics
 11 April 2014 
Predictors of corticosteroid treatment outcomes for ulcerative colitis
 11 April 2014 
Antibiotic combination therapy for ulcerative colitis
 10 April 2014 
Mortality in Crohn's disease
 10 April 2014 
Prophylaxis against venous thromboembolism in hospitalized ulcerative colitis
 10 April 2014 
Probiotic treatment and infant colic
 09 April 2014 
Preventing death in general intensive care
 09 April 2014 
Neoplasm risk after polypectomy
 09 April 2014 
Disclosure program and gastroenterology-related claims
 08 April 2014 

Regurgitation and health-related quality of life in GERD

 08 April 2014 
H. pylori resistance to antibiotics
 08 April 2014 
Management of chronic diarrhea
 07 April 2014 
Meat intake and liver cancer
 07 April 2014 
Gastrointestinal angiodysplastic lesions
 07 April 2014 
Adenoma detection and colorectal cancer risk
 04 April 2014 
Stool DNA tests for colorectal cancer
 04 April 2014 
PET-CT predicts outcome in colorectal liver metastases
 04 April 2014 

Prophylaxis of post-ERCP pancreatitis

 03 April 2014 
Management of esophageal or gastric variceal bleeding
 03 April 2014 
Exclusionary diets for IBD
 03 April 2014 
Mortality with chronic pancreatitis
 02 April 2014 
Disease course of early-onset pediatric IBD
 02 April 2014 
Risk of liver fibrosis progression in chronic hep B
 02 April 2014 
Colorectal cancer and patient survival
 01 April 2014 
Outcomes in patients with Hep C
 01 April 2014 
Diagnosis of functional dyspepsia
 01 April 2014 
Genetic risk factors for stenosis and infections in primary sclerosing cholangitis
 31 March 2014 
Diet-gene interactions and Crohn's
 31 March 2014 
Transjugular intrahepatic portosystemic stent-shunts in Budd–Chiari syndrome
 31 March 2014 
Hepatic decompensation in antiretroviral-treated patients
 28 March 2014 
Glucocorticoids and mortality after colorectal cancer surgery
 28 March 2014 
Long-term metformin use and gastric cancer risk
 28 March 2014 
Distance from a liver transplant center and survival
 27 March 2014 
Radiofrequency ablation vs endoscopy for Barrett's
 27 March 2014 
Omega-3 fatty acid and Crohn's disease
 27 March 2014 
Thromboembolism prophylaxis in IBD
 26 March 2014 
Disparities in evaluation of rectal bleeding
 26 March 2014 
Prediction of H. pylori status after endoscopy
 26 March 2014 
Fatigue and depression in IBD
 25 March 2014 
Depression risk in IBD
 25 March 2014 
Fecal incontinence in the USA
 25 March 2014 
Circulating gastrin and colorectal carcinoma risk
 24 March 2014 
Parental-rearing styles in IBS
 24 March 2014 
Endocannabinoid system in liver disease
 24 March 2014 
Maternal iron supplementation during pregnancy
 21 March 2014 
Eosinophilic esophagitis in the United States
 21 March 2014 
Chemoradiotherapy for anal cancer in HIV patients

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2014 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us