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News

Burden of comedication among patients with IBD

Patients with IBD have increased medication use, particularly of analgesic and psychiatric drugs, reports the latest issue of Inflammatory Bowel Diseases.

News image

Polypharmacy is of growing concern in the chronically ill, including individuals with inflammatory bowel disease (IBD).

Dr Jessie Buckley and colleagues described the prevalence and predictors of non-IBD medication use, and compared drug use among individuals with and without IBD.

The team evaluated members of health plans included in the Thomson Reuters MarketScan databases with continuous enrollment during 2009 and 2010.

Patients with IBD were identified through diagnosis codes and IBD medication dispensings and matched to 5 individuals without IBD.

Psychiatric drug dispensings were more common among female IBD patients
Inflammatory Bowel Diseases

The prevalences of dispensed prescriptions for analgesics, psychiatric medications, and broad drug classes defined by the Anatomic Therapeutic Classification system were estimated.

Predictors of non-IBD medication use and comparisons of drug use by IBD status were evaluated using logistic regression.

The research team found that the prevalence of medication use was higher among patients with IBD than matched members of the general population for nearly every drug class examined, including narcotic analgesics, nonnarcotic analgesics, anxiolytics/sedatives/hypnotics, and antidepressants.

The team noted that medicaid insurance, middle age, gastrointestinal surgery, Crohn's disease, and increasing number of inpatient, and outpatient, and prescription events were significantly associated with analgesic and psychiatric medication use among patients with IBD.

Psychiatric drug dispensings were more common among female IBD patients than male patients.

Dr Buckley's team comments, "Patients with IBD have increased medication use, particularly of analgesic and psychiatric drugs."

"IBD care providers should be aware of polypharmacy and its potential for drug interactions."

Inflamm Bowel Dis 2013: 19(13): 2725-2736
11 December 2013

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