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News

Multiple rapid swallow responses during esophageal high-resolution manometry

Multiple rapid swallow responses during esophageal high-resolution manometry reflect esophageal body peristaltic reserve, reports the latest issue of the American Journal of Gastroenterology.

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Dysphagia may develop following antireflux surgery as a consequence of poor esophageal peristaltic reserve.

Dr Anisa Shaker and colleagues from Missouri, USA hypothesized that suboptimal contraction response following multiple rapid swallows (MRS) could be associated with chronic transit symptoms following antireflux surgery.

Wet swallow and MRS responses on esophageal high-resolution manometry (HRM) were characterized collectively in the esophageal body, and individually in each smooth muscle contraction segment in 63 patients undergoing antireflux surgery, and in 18 healthy controls.

The researchers assessed dysphagia using symptom questionnaires.

Augmentation of smooth muscle contraction was seen in only 11% with late postoperative dysphagia
American Journal of Gastroenterology

The MRS/wet swallow ratios were calculated for S2 and S3 peak amplitudes and DCI.

The researchers compared MRS responses in patients with and without late postoperative dysphagia following antireflux surgery.

Augmentation of smooth muscle contraction as measured collectively by DCI was seen in only 11% with late postoperative dysphagia, compared with 64% in those with no dysphagia, and 78% in controls.

The team found similar results with S3 but not S2 peak amplitude ratios.

Receiver operating characteristics identified a DCI MRS/wet swallow ratio threshold of 0.85 in segregating patients with late postoperative dysphagia from those with no postoperative dysphagia with a sensitivity of 0.67, and specificity of 0.64.

Dr Shaker's team concludes, "Lack of augmentation of smooth muscle contraction following MRS is associated with late postoperative dysphagia following antireflux surgery, suggesting that MRS responses could assess esophageal smooth muscle peristaltic reserve."

"Further research is warranted to determine if antireflux surgery needs to be tailored to the MRS response."

Am J Gastroenterol 2013; 108:1706–1712
14 November 2013

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