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Sequential vs standard triple therapy for  H. pylori infection in children

The latest issue of the Alimentary Pharmacology & Therapeutics compares sequential with standard triple therapy for Helicobacter pylori infection in Chinese children.

News image

Studies have showed that 10-day sequential treatment regimen achieved higher Helicobacter pylori eradication rate than standard triple therapies.

Dr Li and colleagues from China compared a 10-day sequential therapy and standard triple therapy in Chinese children with H. pylori infection.

Eradication achieved with the 10-day sequential therapy was higher than either the 7-day
Alimentary Pharmacology & Therapeutics

The research team conducted a prospective, multicenter, open-label, randomized controlled trial in 4 tertiary medical centers in China.

Children with H. pylori gastritis were randomly assigned to a 10-day sequential therapy consisting of omeprazole and amoxicillin for 5 days followed by omeprazole, clarithromycin and metronidazole for the remaining 5 days, or 7-day or 10-day standard triple therapy comprising of omeprazole, amoxicillin and clarithromycin.

H. pylori eradication was assessed by  H. pylori stool antigen test.

A total of 360 patients were included.

The eradication rate achieved with the 10-day sequential therapy was significantly higher than either the 7-day or 10-day standard triple treatment, either by the intention-to-treat analysis or per-protocol analysis.

Dr Li's team comments, "The 10-day sequential regimen was significantly more effective than standard 7-day or 10-day triple regimens in eradicating  H. pylori infection in Chinese children."

Aliment Pharmacol Ther 2013: 38(10): 1230–1235
12 November 2013

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