Studies have showed that 10-day sequential treatment regimen achieved higher Helicobacter pylori eradication rate than standard triple therapies.
Dr Li and colleagues from China compared a 10-day sequential therapy and standard triple therapy in Chinese children with H. pylori infection.
|Eradication achieved with the 10-day sequential therapy was higher than either the 7-day|
|Alimentary Pharmacology & Therapeutics|
The research team conducted a prospective, multicenter, open-label, randomized controlled trial in 4 tertiary medical centers in China.
Children with H. pylori gastritis were randomly assigned to a 10-day sequential therapy consisting of omeprazole and amoxicillin for 5 days followed by omeprazole, clarithromycin and metronidazole for the remaining 5 days, or 7-day or 10-day standard triple therapy comprising of omeprazole, amoxicillin and clarithromycin.
H. pylori eradication was assessed by H. pylori stool antigen test.
A total of 360 patients were included.
The eradication rate achieved with the 10-day sequential therapy was significantly higher than either the 7-day or 10-day standard triple treatment, either by the intention-to-treat analysis or per-protocol analysis.
Dr Li's team comments, "The 10-day sequential regimen was significantly more effective than standard 7-day or 10-day triple regimens in eradicating H. pylori infection in Chinese children."