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News

Staging of intestinal- and diffuse-type gastric cancers

The most recent issue of the Alimentary Pharmacology & Therapeutics reports on the staging of intestinal- and diffuse-type gastric cancers with the OLGA and OLGIM staging systems.

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Operative link on gastritis assessment (OLGA) and Operative link on gastric intestinal metaplasia assessment (OLGIM) staging systems have been proposed for gastric cancer risk estimation.

Dr Cho and colleagues from Korea validated the OLGA and OLGIM staging systems in a region with high risk of gastric cancer.

The team performed a retrospective study that included 474 gastric cancer patients and age- and sex-matched health screening control persons in a cancer centre hospital.

The researchers classified gastritis patterns according to the OLGA and OLGIM systems using the histological database that a pathologist prospectively evaluated using the updated Sydney system.

The association was more significant for intestinal-type gastric cancer
Alimentary Pharmacology & Therapeutics

Gastric cancer risk according to the OLGA and OLGIM stages was evaluated using logistic regression analysis.

The team found that more gastric cancer patients had OLGA stages III–IV than controls, particularly among patients with intestinal-type gastric cancers compared with diffuse-type gastric cancers.

OLGA stages III and IV were significantly associated with increased risk of gastric cancer in multivariate analysis.

The association was more significant for intestinal-type, but not diffuse-type gastric cancer.

OLGIM stages from I to IV were significantly associated with increased risk of both intestinal-type, and diffuse-type gastric cancer, with a significantly increasing trend.

Dr Cho's team concludes, "As high OLGA and OLGIM stages are independent risk factors for gastric cancer, the staging systems may be useful for risk assessment in high-risk regions, especially for intestinal-type gastric cancer."

Aliment Pharmacol Ther 2013: 38(10): 1292–1302
08 November 2013

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