Professor Julián Panés and colleagues from Spain determined the diagnostic accuracy of magnetic resonance colonography (MRC) for the evaluation of disease activity and severity in patients with ulcerative colitis using endoscopy as the reference standard.
The team found that 50 patients with ulcerative colitis underwent colonoscopy and MRC for the evaluation of disease activity.
All patients were prospectively and consecutively included.
|The MRC-S index strongly correlated with the assessment of the radiologists |
Endoscopic activity was evaluated globally and on a segment basis using the modified Baron score (MBS), and also classified as absent, mild to moderate or severe.
MRC parameters evaluated in each segment included wall thickness, pre- and post-contrast wall signal intensity, relative contrast enhancement, mural edema, ulcers, enlarged lymph nodes and the comb sign.
The research team found that independent predictors for endoscopic activity on a segment basis were relative contrast enhancement, presence of edema, enlarged lymph nodes, and the comb sign.
The team noted that a segmental simplified MRC index of more than 1 detected endoscopic inflammation with high diagnostic accuracy.
The researchers noted that a MRC-S index of more than 2 detected severe lesions with high sensitivity, and specificity with an AUC of 0.91.
The MRC-S index strongly correlated with the MBS, and with the subjective assessment of the radiologists for the evaluation of disease severity.
Professor Panés's team commented, "MRC has a high accuracy for the diagnosis of disease activity and severity in ulcerative colitis."