Help
Subscribe


All of GastroHep is now free access! - Click here to register Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Simple noninvasive systems predict long-term outcomes in NAFLD

The latest issue of Gastroenterology investigates simple noninvasive systems predict long-term outcomes of patients with nonalcoholic fatty liver disease.

News image

Some patients with nonalcoholic fatty liver disease (NAFLD) develop liver-related complications, and have higher mortality than other patients with NAFLD.

Dr Paul Angulo and colleagues from Kentucky, USA determined the accuracy of simple, noninvasive scoring systems in identification of patients at increased risk for liver-related complications or death.

The research team performed a retrospective, international, multicenter cohort study of 320 patients diagnosed with NAFLD, based on liver biopsy analysis through 2002 and followed through 2011.

Patients were assigned to mild-, intermediate-, or high-risk groups based on cut-off values for 2 of the following; NAFLD fibrosis score, aspartate aminotransferase/platelet ratio index, FIB-4 score, and BARD score.

Outcomes included liver-related complications and death or liver transplantation.

14% of patients developed liver-related events
Gastroenterology

The researchers used multivariate Cox proportional hazard regression analysis to adjust for relevant variables and calculate adjusted hazard ratios.

During a median follow-up period of 105 months, 14% of patients developed liver-related events, and 13% died or underwent liver transplantation.

The adjusted hazard ratios for liver-related events in the intermediate-risk and high-risk groups, compared with the low-risk group, were 8, and 34, respectively.

Based on NAFLD fibrosis score, the adjusted hazard ratios for liver-related events in the intermediate-risk and high-risk groups were 8.8, and 21 based on the aspartate aminotransferase/platelet ratio index; and 6.2 and 6.6 based on the BARD score.

The adjusted hazard ratios for death or liver transplantation in the intermediate-risk and high-risk groups compared with the low-risk group were 4.2, and 9.8, respectively, based on the NAFLD fibrosis scores.

Based on aspartate aminotransferase/platelet ratio index and FIB-4 score, only the high-risk group had a greater risk of death or liver transplantation.

Dr Angulo's team concludes, "Simple noninvasive scoring systems help identify patients with NAFLD who are at increased risk for liver-related complications or death."

"NAFLD fibrosis score appears to be the best indicator of patients at risk."

"The results of this study require external validation."

Gastroenterology 2013: 145(4): 782-789
08 October 2013

Go to top of page Email this page Email this page to a colleague

 24 April 2014

Advanced search
 24 April 2014 
Imaging liver fat in children
 24 April 2014 
Vitamin D levels in adults with Crohn's disease
 24 April 2014 
Gut microbiota in IBS
 23 April 2014 
Cancer risk after resection of polypoid dysplasia
 23 April 2014 
Fecal microbiota transplantation therapy
 23 April 2014 
Colorectal cancer risk in MUTYH mutation carriers
 22 April 2014 
Endoscopy guidelines to select patients for colonoscopy
 22 April 2014 
PPI use and cancer in Barrett's
 22 April 2014 
Ledipasvir and sofosbuvir for HCV genotype 1
 17 April 2014 
Screening for low bone mineral density among ulcerative colitis
 17 April 2014 
Diabetes mellitus and acute pancreatitis
 17 April 2014 
Bowel cleansing for colonoscopy
 16 April 2014 
Evaluating pharmacologic agents in IBS
 16 April 2014 
Isotretinoin and IBD risk
 16 April 2014 
Mortality in bleeding Mallory-Weiss syndrome vs peptic ulcer bleeding
 15 April 2014 
Dietary fat and risk of IBD
 15 April 2014 
Quality of life in microscopic colitis
 15 April 2014 
New prognostic score for cirrhosis
 14 April 2014 

5-aminosalicylates in early pregnancy and congenital malformation risk

 14 April 2014 
Changing liver cancer mortality rates in the United States
 14 April 2014 
Inflammatory sacroiliitis by MRI in IBD
 11 April 2014 
H pylori resistance to antibiotics
 11 April 2014 
Predictors of corticosteroid treatment outcomes for ulcerative colitis
 11 April 2014 
Antibiotic combination therapy for ulcerative colitis
 10 April 2014 
Mortality in Crohn's disease
 10 April 2014 
Prophylaxis against venous thromboembolism in hospitalized ulcerative colitis
 10 April 2014 
Probiotic treatment and infant colic
 09 April 2014 
Preventing death in general intensive care
 09 April 2014 
Neoplasm risk after polypectomy
 09 April 2014 
Disclosure program and gastroenterology-related claims
 08 April 2014 

Regurgitation and health-related quality of life in GERD

 08 April 2014 
H. pylori resistance to antibiotics
 08 April 2014 
Management of chronic diarrhea
 07 April 2014 
Gastrointestinal angiodysplastic lesions
 07 April 2014 
Meat intake and liver cancer
 07 April 2014 
Adenoma detection and colorectal cancer risk
 04 April 2014 
Stool DNA tests for colorectal cancer
 04 April 2014 
PET-CT predicts outcome in colorectal liver metastases
 04 April 2014 

Prophylaxis of post-ERCP pancreatitis

 03 April 2014 
Management of esophageal or gastric variceal bleeding
 03 April 2014 
Exclusionary diets for IBD
 03 April 2014 
Mortality with chronic pancreatitis
 02 April 2014 
Disease course of early-onset pediatric IBD
 02 April 2014 
Risk of liver fibrosis progression in chronic hep B
 02 April 2014 
Colorectal cancer and patient survival
 01 April 2014 
Outcomes in patients with Hep C
 01 April 2014 
Diagnosis of functional dyspepsia
 01 April 2014 
Genetic risk factors for stenosis and infections in primary sclerosing cholangitis
 31 March 2014 
Diet-gene interactions and Crohn's
 31 March 2014 
Transjugular intrahepatic portosystemic stent-shunts in Budd–Chiari syndrome
 31 March 2014 
Hepatic decompensation in antiretroviral-treated patients
 28 March 2014 
Glucocorticoids and mortality after colorectal cancer surgery
 28 March 2014 
Long-term metformin use and gastric cancer risk
 28 March 2014 
Distance from a liver transplant center and survival
 27 March 2014 
Radiofrequency ablation vs endoscopy for Barrett's
 27 March 2014 
Omega-3 fatty acid and Crohn's disease
 27 March 2014 
Thromboembolism prophylaxis in IBD
 26 March 2014 
Disparities in evaluation of rectal bleeding
 26 March 2014 
Prediction of H. pylori status after endoscopy
 26 March 2014 
Fatigue and depression in IBD

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2014 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us