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News

Is iron deficiency without anemia associated with fatigue in IBD

A study in September's issue of the American Journal of Gastroenterology investigates whether iron deficiency in the absence of anemia is associated With Fatigue in Inflammatory Bowel Disease?

News image

Dr Lesley Graff and colleagues from Canada explored whether iron deficiency in the absence of anemia is associated with fatigue in inflammatory bowel disease (IBD).

The researchers assessed iron deficiency and anemia in 280 participants from the population-based Manitoba IBD Cohort Study.

Iron deficiency was identified in 20% with Crohn’s disease, and 27% with ulcerative colitis.

Iron deficiency was identified in 20% with Crohn’s disease
American Journal of Gastroenterology

The research team identified anemia overall in 18%, with 230 who were nonanemic.

In the nonanemic subgroup, there were no significant differences between iron-deficient and -sufficient groups in mean fatigue levels or proportions with problematic fatigue.

The research team observed no unique contribution of iron deficiency to problematic fatigue after adjustment for active disease and anemia.

Dr Graff's team concluded, "There was no evidence of an association between iron deficiency and fatigue in the absence of anemia, suggesting that iron deficiency is not a clinically relevant contributor to fatigue in IBD."

Am J Gastroenterol 2013; 108:1392–1397
25 September 2013

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