The relationship between symptom improvement and acceleration of gastric emptying for different drugs used in the treatment of idiopathic and diabetic gastroparesis is uncertain.
Dr Jan Tack and colleagues from Belgium examined the study-specific correlations between symptom improvement and gastric emptying, and performed a meta-regression analysis of the association across multiple studies.
The MEDLINE database was searched, and only controlled trials or trials with an established effective comparator that compared both symptom improvement and gastric emptying were included.
|No study reported a correlation between symptom improvement and gastric emptying|
|American Journal of Gastroenterology|
The research team identified studies for metoclopramide, domperidone, cisapride, erythromycin, botulinum toxin, and levosulpiride.
Even though most drugs concomitantly improved symptoms and accelerated gastric emptying, the team found no study reported a significant correlation between symptom improvement and gastric emptying.
Moreover, a correlation analysis over all studies using meta-regression did not show a significant relationship between symptom improvement and gastric emptying.
Dr Tack's team concludes, "In this review, no evidence of a relationship between symptom improvement and gastric emptying was identified for different drugs used for the treatment of gastroparesis."
"This finding questions the use of gastric emptying measurement to direct drug development for gastroparesis."