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Thrombocytosis is associated with iron deficiency anemia in IBD

The latest issue of the European Journal of Gastroenterology & Hepatology investigates the association between thrombocytosis and iron deficiency anemia in inflammatory bowel disease.

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Thrombocytosis and iron deficiency anemia are frequent complications of inflammatory bowel disease.

Dr Voudoukis and colleagues investigated the correlation between iron deficiency anemia and thrombocytosis in inflammatory bowel disease patients.

A total of 198 consecutive inflammatory bowel disease patients, and 102 healthy controls participated in the study.

The doctors analyzed platelets, mean platelet volume, platelet distribution width, plateletcrit, hematocrit levels, hemoglobulin levels, mean corpuscular volume, red cell distribution width, ferritin levels, soluble transferrin receptor levels, the sTfR-F index, and vitamin B12 and folate levels.

Thrombocytosis was defined as an absolute number of platelets greater than 400k/µl.

The median value for platelets was 289k/µl
European Journal of Gastroenterology and Hepatology

The team also correlated disease activity indices as well as C-reactive protein with the study parameters.

The inflammatory bowel disease patients demonstrated decreased HCT levels, Hb levels, mean corpuscular volume, mean platelet volume, and ferritin levels, and an increased absolute platelets count, red cell distribution width, platelet distribution width, plateletcrit, sTfR and sTfR-F index compared with healthy controls.

The research team reported that 27 patients exhibited thrombocytosis.

The median value for platelets was 289k/µl, for Hb levels was 13.4 g/dl, for ferritin levels was 36.6 ng/ml, and for sTfR-F was 0.82 mg/l.

The platelets in inflammatory bowel disease patients correlated with hematocrit levels, hematocrit levels, mean corpuscular volume, red cell distribution width, iron levels, ferritin levels, soluble transferrin receptor, soluble transferrin receptor-F, C-reactive protein levels, Simple Clinical Colitis Activity Index, and Crohn’s Disease Activity Index.

The team found on further analysis, that only hemoglobulin levels, red cell distribution width, C-reactive protein levels, ferritin levels, and sTfR-F remained significant.

None of the aforementioned was observed in the control group.

Dr Voudoukis' team commented, "The absolute platelets count seems to correlate with iron deficiency anemia parameters and disease activity in inflammatory bowel disease patients."

"Controlling the inflammation and managing iron deficiency could lead to reversal of thrombocytosis in inflammatory bowel disease patients."

Euro J of Gastroenterol & Hepatol 2013: 25(10): 1212-1216
20 September 2013

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