Help
Subscribe


Submit Videos to GastroHep Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Scoring systems for the management of alcoholic hepatitis

A prospective study reported in the latest issue of Alimentary Pharmacology & Therapeutics compares scoring systems for the management of alcoholic hepatitis.

News image

The assessment of alcoholic hepatitis remains controversial.

Several scores have been developed or used for this purpose.

Dr Lafferty and colleagues from the United Kingdom used of the Glasgow Alcoholic Hepatitis Score, the Discriminant Function, Model for End-Stage Liver Disease and the age, bilirubin, INR and creatinine scores as well as scores to assess corticosteroid response in the management of alcoholic hepatitis.

A total of 182 patients were studied prospectively.

The Glasgow Alcoholic Hepatitis Score, Model for End-Stage Liver Disease, age, bilirubin, INR and creatinine and DF scores were recorded on admission and serially over the first week of hospital management.

Treatment with corticosteroids or pentoxifylline was considered if the Glasgow Alcoholic Hepatitis Score was 9.

Response to corticosteroids can be assessed using the Lille Score
Alimentary Pharmacology & Therapeutics

The research team found no differences in outcome between favourable scores as per recommended cut-off points.

Patients with a Glasgow Alcoholic Hepatitis Score less than 9 had similar outcome whether their Model for End-Stage Liver Disease, Discriminant Function or age, bilirubin, INR and creatinine scores were favorable or unfavorable.

The doctors observed that treated patients with a Glasgow Alcoholic Hepatitis Score of 9 had a significantly better 90-day outcome than those who did not.

Patients treated with corticosteroids who had a fall in bilirubin of 25% after a week of treatment had an improved survival.

The Lille Score or a 25% fall in bilirubin had greater sensitivities than an early change in bilirubin level to assess treatment response.

Dr Lafferty's team concludes, "In this single-centre study, a Glasgow Alcoholic Hepatitis Score of 9 identified patients who may benefit from treatment of alcoholic hepatitis."

"Intention-to-treat randomized-controlled trials using a Glasgow Alcoholic Hepatitis Score of 9 as the threshold for treatment are needed to validate these findings."

"Response to corticosteroids can be assessed using the Lille Score or by a 25% fall in bilirubin."

Aliment Pharmacol Ther 2013: 38(6): 603–610
20 September 2013

Go to top of page Email this page Email this page to a colleague

 23 September 2014

Advanced search
 23 September 2014 
Recurrence of Barrett's neoplasia after resection
 23 September 2014 
Abnormal prion protein in appendixes
 23 September 2014 
Upper GI bleeding with drug combinations
 22 September 2014 
Anorectal function after low anterior resection
 22 September 2014 

Anorectal stricture in Crohn's

 22 September 2014 
Malignancies in celiac disease
 19 September 2014 
Adhesions in abdominal and pelvic surgery
 19 September 2014 
Repeat colonoscopy among US Medicare
 19 September 2014 
Progression to liver cancer in HCV-infected Veterans
 18 September 2014 
Patient improvement following sacral neuromodulation
 18 September 2014 
Autoimmune diseases in functional gastrointestinal disorders
 18 September 2014 
New diagnostic score for hepatic steatosis
 17 September 2014 
Orange juice intake for bowel preparation
 17 September 2014 
Treatment of fistulising perianal Crohn's disease
 17 September 2014 
Interval colorectal cancers
 16 September 2014 
Fiber treats IBS
 16 September 2014 
Resected biliary tract cancer
 16 September 2014 
Postoperative adhesions in digestive surgery
 15 September 2014 
Fecal transplantation for C.diff infection
 15 September 2014 
Prunes and GI function
 15 September 2014 
Antidepressants for IBS
 12 September 2014 
Metabolic syndrome delays HBeAg seroclearance
 12 September 2014 
Drug-induced liver disease
 12 September 2014 
Management of complex colon polyps
 11 September 2014 
Hepatobiliary cirrhosis risk after organ transplant
 11 September 2014 
Sofosbuvir plus peginterferon/ribavirin for HCV
 11 September 2014 
Patient perceptions in celiac disease
 10 September 2014 
Adhesions in abdominal and pelvic surgery
 10 September 2014 
Acute kidney injury after colonoscopy
 10 September 2014 
Management algorithm for endoscopic mucosal resection of colonic lesions
 09 September 2014 
PPIs and spontaneous bacterial peritonitis in cirrhosis
 09 September 2014 
Neutrophil function and mortality in cirrhosis
 09 September 2014 
MELD and liver cancer survival
 08 September 2014 
Vagal nerve blockade and morbid obesity
 08 September 2014 
Comparison of diet programs in overweight and obese adults
 08 September 2014 
Long-term follow-up after bariatric surgery
 05 September 2014 
Healing rates in reflux esophagitis
 05 September 2014 
Progression of environmental enteropathy
 05 September 2014 
Diabetes and liver transplant outcomes
 04 September 2014 
Colectomy rates for refractory ulcerative colitis
 04 September 2014 
Infliximab prevents long-term Crohn’s disease recurrence
 04 September 2014 
Histological recovery with gluten-free diet in celiac disease
 03 September 2014 
Predictors of response in Crohn's disease
 03 September 2014 
Diagnosis of atrophic gastritis
 03 September 2014 
Safety of reinitiation of infliximab therapy
 02 September 2014 
SSRIs and depression in Hep C
 02 September 2014 
Bariatric surgery for obesity
 02 September 2014 
Eosinophilic esophagitis in adults
 01 September 2014 
Risks with anti-TNF in pediatric IBD
 01 September 2014 
Fecal hemoglobin and colorectal cancer screening
 01 September 2014 
Genetic variants in alcoholic liver disease
 29 August 2014 
Gluten-free diet for asymptomatic celiac disease
 29 August 2014 
NSAID-induced small intestinal injury and diaphragm disease
 29 August 2014 
Symptom evaluation in functional dyspepsia
 28 August 2014 
Detection of gastroesophageal reflux symptoms
 28 August 2014 
Colorectal-cancer mortality after adenoma removal
 28 August 2014 
Predictoris of C. diff in out-patients
 27 August 2014 
Endoscopy outcomes in community hospital vs tertiary academic centers
 27 August 2014 
UV exposure and IBD hospitalizations
 27 August 2014 
Hepatocellular carcinoma screening in liver disease

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2014 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us