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 08 February 2016

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News

Mortality associated with alcohol-related liver disease

The most recent issue of the Alimentary Pharmacology & Therapeutics investigates mortality associated with alcohol-related liver disease.

News image

Excessive alcohol use has been reported to be responsible for 80,000 annual deaths in the United States.

However, the exact cause of death related to the excessive use of alcohol has not been fully explored.

Dr Trimble and colleagues from Virginia, USA assessed the effect of alcoholic liver disease on all-cause, liver-related and cardiovascular mortality using population-based data.

Participants with alcoholic liver disease had increased risk for liver-related mortality
Alimentary Pharmacology & Therapeutics

Data were obtained from the Third National Health and Nutrition Examination Survey Linked Mortality Files.

Alcohol consumption was estimated as grams per day.

Multivariate Cox proportional hazards model was utilised to assess the effects of alcoholic liver disease on follow-up time to mortality from all causes, cardiovascular disease and liver disease.

The research team included a total of 8,306 participants.

The team observed that mortality follow-up data were available for a median time of 178 months.

The team found that participants with alcoholic liver disease had increased risk for liver-related mortality, but not for overall mortality or cardiovascular mortality.

Dr Trimble's team concludes, "Alcoholic liver disease increases the risks for liver-related mortality but not for cardiac or overall mortality."

Aliment Pharmacol & Ther 2013: 38(6): 596–602
19 September 2013

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