Help
Subscribe


All of GastroHep is now free access! - Click here to register Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Factors that predict short-term intensive care unit mortality in cirrhosis

The most recent issue of Clinical Gastroenterology & Hepatology identifies factors that predict short-term intensive care unit mortality in patients with cirrhosis.

News image

Despite advances in critical care medicine, the mortality rate is high among critically ill patients with cirrhosis.

Dr Ranjeeta Bahirwani and colleagues from Pensylvania, USA identified factors that predict early mortality among patients with cirrhosis admitted to the intensive care unit, and developed a risk-stratification model.

The doctors collected data from patients with cirrhosis admitted to the intensive care unit at Indiana University intensive care unit from 2006, through 2009, or at the University of Pennsylvania intensive care unit from 2005, through 2010.

Factors associated with mortality within 7 days of admission were determined by logistic regression analyses.

A MELD score of 32 at ICU admission had a mortality of 54%
Clinical Gastroenterology and Hepatology

A model was constructed based on the predictive parameters available on the first day of intensive care unit admission in the Indiana University intensive care unit cohort, and then validated in the Penn-intensive care unit cohort.

The researchers found that Model for End-stage Liver Disease scores at intensive care unit admission were 25 in the Indiana University intensive care unit cohort, and 32 in the Penn-intensive care unit cohort.

The team found that corresponding 7-day mortalities were 28%, and 54%, respectively.

Model for End-stage Liver Disease score odds ratio of 1.13 and mechanical ventilation were associated independently with 7-day mortality in the Indiana University intensive care unit.

A model based on these 2 variables separated Indiana University intensive care unit patients into low-, medium-, and high-risk groups.

The team observed that these groups had 7-day mortalities of 9%, 27%, and 74%, respectively.

The team applied the model to the Penn–intensive care unit cohort, and found that the low-, medium-, and high-risk groups had 7-day mortalities of 33%, 56%, and 71%, respectively.

Dr Bahirwani's team concludes, "A model based on Model for End-stage Liver Disease score and mechanical ventilation on day 1 can stratify risk of early mortality in patients with cirrhosis admitted to the intensive care unit."

"More studies are needed to validate this model and to enhance its clinical utility."

Clin Gastroenterol and Hepatol 2013: 11(9): 1194-1200
18 September 2013

Go to top of page Email this page Email this page to a colleague

 03 March 2015

Advanced search
 03 March 2015 
EPHX1 polymorphism and esophageal cancer risk
 03 March 2015 
GI bleeding in chronic kidney disease patients on aspirin
 03 March 2015 
Risk of anastomotic leak after colectomy
 02 March 2015 
Genes and early diagnosis of IBD
 02 March 2015 
Assessment of GERD
 02 March 2015 
Liver disease in patients awaiting liver transplant
 27 February 2015 
Obesity and weight-loss therapy
 27 February 2015 
MRE performance in staging liver fibrosis
 27 February 2015 
Bleeding in diverticulosis
 26 February 2015 
Familial colorectal cancer risk and primary cancer
 26 February 2015 
Herbal products and the liver
 26 February 2015 
Questionnaires for GERD
 25 February 2015 
Exercise and NAFLD
 25 February 2015 
IBD in Korea
 25 February 2015 
Immunosuppressive therapy and T. whipplei
 24 February 2015 
Clinical trials in pediatric IBD
 24 February 2015 
Reducing health care costs in IBD
 24 February 2015 
GI bleeding after anticoagulation interruption
 23 February 2015 
Visceral abdominal obesity and IBS
 23 February 2015 
Crohn's outcomes with infliximab
 23 February 2015 
Intestinal microbiota and celiac disease
 20 February 2015 
H. pylori eradication
 20 February 2015 
Antiviral treatment and Hep C outcomes
 20 February 2015 
C. diff testing in IBD
 19 February 2015 
Intestinal microbiota in IBS
 19 February 2015 
Peptic ulcer bleeding mortality in liver disease
 19 February 2015 
Fecal microbial transplant in active Crohn's disease
 18 February 2015 
Genetic testing and GI cancers
 18 February 2015 
Placebo analgesia in functional abdominal pain
 18 February 2015 
Successful Hep C virus therapy
 17 February 2015 
Quality measures and colonoscopist selection
 17 February 2015 
Global incidence of esophageal cancer
 17 February 2015 
Anti-viral treatment and survival in Hep C
 16 February 2015 
Saliva for the diagnosis of GERD
 16 February 2015 
H pylori eradication therapy
 16 February 2015 
Medical marijuana for digestive disorders
 13 February 2015 
Beta-blockers in cirrhosis
 13 February 2015 
Liver disease and peptic ulcer bleeding
 13 February 2015 
Prevalence of microscopic colitis
 12 February 2015 
Liver disease in chronic Hep C
 12 February 2015 
Patient-reported outcomes in Hep C
 12 February 2015 
Patients’ colonoscopist selection
 11 February 2015 
Guidelines for the diagnosis of hepatocellular carcinoma
 11 February 2015 
Hepatic decompensation in Hep C cirrhosis
 11 February 2015 
NAFLD and CVD
 10 February 2015 
Percutaneous endoscopic gastrostomy
 10 February 2015 
Factors that influence hepatic steatosis
 10 February 2015 
Gene variants and Crohn's susceptibility
 09 February 2015 
Factors that influence gallstone surgery
 09 February 2015 
Factors associated with increased mortality in cirrhosis
 09 February 2015 
Use of immunomodulators in IBD
 06 February 2015 
Colorectal cancer risk in IBD
 06 February 2015 
H. pylori and peptic ulcer bleeding
 06 February 2015 
IBS and somatization
 05 February 2015 
GERD, dyspepsia and IBS symptoms
 05 February 2015 
Quality of life in Crohn's after antitumor necrosis factor agents
 05 February 2015 
Thalidomide and refractory Crohn's
 04 February 2015 
Telemedicine in IBD
 04 February 2015 
Infliximab and muscle wasting in Crohn's
 04 February 2015 
Resistance mutations in chronic Hep B

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2015 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us