Help
Subscribe


All of GastroHep is now free access! - Click here to register Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Response to therapy among patients with acute exacerbation of chronic Hep C

The latest issue of Clinical Gastroenterology & Hepatology investigates clinical presentation, outcome, and response to therapy among patients with acute exacerbation of chronic Hepatitis C.

News image

The slow asymptomatic progression of chronic hepatitis C can be interrupted by an acute exacerbation, characterized by increased serum levels of alanine aminotransferase and bilirubin and other symptoms of acute hepatitis.

Dr Evangelista Sagnelli and colleagues provided more information about the clinical presentation of acute exacerbation of chronic hepatitis C.

The research team identified 82 consecutive patients, from 2 locations in Italy, who had an acute exacerbation of chronic hepatitis C from 2005 through 2010.

The team followed them up for a median period of 36 months.

Hepatitis C virus genotype 2 was detected in 46% of cases
Clinical Gastroenterology and Hepatology

These cases were hepatitis C virus RNA positive, hepatitis B surface antigen-negative, and had not received anti-hepatitis C virus therapy.

The cases were matched with 82 subjects with hepatitis C without reactivation for age, sex, and hepatitis C virus genotype.

The researchers followed 69 cases, and 73 controls were followed up for at least 2 years.

Liver biopsy specimens had been taken from 23 cases and 31 controls—once before enrollment in the study and once during the follow-up period.

The research team detected hepatitis C virus genotype 2 in 46% of cases, and hepatitis C virus genotype 1 was detected in 44%.

Among cases, the mean alanine aminotransferase level was 1063 IU/dL, and the mean total bilirubin level was 16 mg/dL.

The doctors analyzed a higher percentage of cases carried the interleukin-28B CC genotype than controls.

Among cases, 44% had a steady increase in alanine aminotransferase level for 56% of these patients, alanine aminotransferase levels returned to baseline values before the acute exacerbation of chronic hepatitis.

Based on comparisons of biopsy specimens, 18 cases and 11 controls had increasing fibrosis, with Ishak scores increasing by more than 2.

The team found that 14 cases and 3 controls had increases in necroinflammation of more than 2 points.

The researchers observed that 32 cases and 38 controls received treatment with pegylated interferon and ribavirin.

A sustained virologic response was achieved in 26 cases and 23 controls.

Dr Sagnelli's team commented, "Although an acute exacerbation of chronic hepatitis is a serious medical condition, most patients achieve a sustained virologic response after treatment with pegylated interferon and ribavirin."

Clin Gastroenterol and Hepatol 2013: 11(9): 1174-1180
19 September 2013

Go to top of page Email this page Email this page to a colleague

 31 October 2014

Advanced search
 31 October 2014 
C. difficile infection with metronidazole
 31 October 2014 
Pediatric NAFLD
 31 October 2014 
Pregnancy complications in celiac disease
 30 October 2014 
Constipation and colorectal cancer
 30 October 2014 
Costs in newly diagnosed patients with chronic constipation
 30 October 2014 
Cirrhosis in women
 29 October 2014 
Quality of life after infection with E. coli
 29 October 2014 
IBS in primary care
 29 October 2014 
Sensorimotor activity in functional dyspepsia
 28 October 2014 
Risk factor for smaller final height in Crohn's
 28 October 2014 
Increased bile acid synthesis in IBS-diarrhea
 28 October 2014 
Successful radiofrequency ablation for Barrett’s
 27 October 2014 
Celiac disease and type 1 diabetes
 27 October 2014 
Gluten awareness among chefs
 27 October 2014 

PPI-responsive esophageal eosinophilia

 24 October 2014 
Olmesartan-associated enteropathy
 24 October 2014 
Opioid use in IBD
 24 October 2014 
NSAIDs and Barrett's risk
 23 October 2014 
Outcomes in hospitalized patients with GI bleeding
 23 October 2014 
Thiopurines and colorectal cancer risk in IBD
 23 October 2014 
Advancing the field of functional GI disorders
 22 October 2014 
Early-TIPSS placement prevents rebleeding
 22 October 2014 
Liver fibrosis prognostic biomarkers in type-2 diabetes
 22 October 2014 
H pylori eradication with multiple drug resistance
 21 October 2014 
Alcohol and Barrett's
 21 October 2014 
Scoring systems for critically ill cirrhotic patients
 21 October 2014 
Aspirin and NAFLD
 20 October 2014 
Adalimumab in secondary loss of response in Crohn's
 20 October 2014 
Drug resistant H pylori eradication
 20 October 2014 
Omega-3 and colorectal cancer
 17 October 2014 
Tumor necrosis factor-alpha inhibitors and pregnancy in IBD
 17 October 2014 
Colorectal testing utilization
 17 October 2014 
Fecal microbiota composition in postinfectious IBS
 16 October 2014 
Risk of Barrett's esophagus
 16 October 2014 
Aspirin tablets and colorectal tumours
 16 October 2014 
Economic impact of IBS
 15 October 2014 
Achieving competency at colonoscopy
 15 October 2014 
Preparation for surgery in Crohn's
 15 October 2014 
Bowel preparations
 14 October 2014 
Colorectal testing utilization in commercially insured US adults
 14 October 2014 
Sustained response to infliximab
 14 October 2014 
IBD management during pregnancy
 13 October 2014 
Predicting PPI response in GERD-related cough
 13 October 2014 
Probiotics in IBS
 13 October 2014 
Use of azathioprine in IBD
 10 October 2014 
NAFLD in the Veterans Administration population
 10 October 2014 
Liver injury from herbals and dietary supplements
 10 October 2014 
Predictors for cecal insertion time
 09 October 2014 
Methotrexate-related liver disease and metabolic syndrome
 09 October 2014 
Biomarkers of acetaminophen overdose patients
 09 October 2014 
Postoperative adhesions in digestive surgery
 08 October 2014 
Gluten introduction in high risk children
 08 October 2014 
Vitamin D and HCC
 08 October 2014 
Feeding intervention in celiac disease infants
 07 October 2014 
Infliximab in pediatric perianal Crohn's
 07 October 2014 
Omega-3 and NAFLD
 07 October 2014 
Endoscopic submucosal dissection in the colorectum 
 06 October 2014 
Clinical indications for computed tomographic colonography
 06 October 2014 
Certolizumab pegol in the treatment of Crohn's
 06 October 2014 
Costs of telaprevir therapy for Hep C

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2014 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us