Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 06 December 2016

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Genetic risk factors for Clostridium difficile infection in ulcerative colitis

This month's issue of the Alimentary Pharmacology & Therapeutics evaluates genetic risk factors for Clostridium difficile infection in ulcerative colitis.

News image

Patients with inflammatory bowel disease are at higher risk for Clostridium difficile infection.

Disruption of gut microbiome and interaction with the intestinal immune system are essential mechanisms for pathogenesis of both Clostridium difficile infection and inflammatory bowel disease.

Dr Ananthakrishnan from Massachusetts, USA and fellow researchers conducted whether genetic polymorphisms associated with susceptibility to inflammatory bowel disease are also associated with risk of Clostridium difficile infection is unknown.

The team evaluated a well-characterized and genotyped cohort of patients with ulcerative colitis to identify clinical risk factors for Clostridium difficile.

The researchers examined if any of the inflammatory bowel disease genetic risk loci were associated withClostridium difficile infection, and compared the performance of predictive models using clinical and genetic risk factors in determining risk of Clostridium difficile infection.

The doctors used a prospective registry of patients from a tertiary referral hospital.

Medical record review was performed to identify all ulcerative colitis patients within the registry with a history of Clostridium difficile infection.

The genetic loci explained 28% of the variance in C difficile risk
Alimentary Pharmacology & Therapeutics

All patients were genotyped on the Immunochip.

The doctors examined the association between the 163 risk loci for inflammatory bowel disease, and risk of Clostridium difficile using a dominant genetic model.

Model performance was examined using receiver operating characteristics curves.

The study included 319 patients of whom 29 developed Clostridium difficile infection.

Female gender and pancolitis were associated with increased risk, while use of anti-TNF was protective against Clostridium difficile infection.

The researchers identified 6 genetic polymorphisms including those at TNFRSF14 that were associated with increased risk while 2 loci were inversely associated.

The research team found that none of the clinical parameters retained significance after adjusting for genetics.

Presence of at least 1 high-risk locus was associated with an increase in risk for Clostridium difficile infection.

Compared to 11% for a clinical model, the genetic loci explained 28% of the variance in Clostridium difficile risk.

Dr Ananthakrishnan's team concludes, "Host genetics may influence susceptibility to Clostridium difficile infection in patients with ulcerative colitis."

Aliment Pharmacol & Ther 2013: 38(5) 522–530
06 September 2013

Go to top of page Email this page Email this page to a colleague

 06 December 2016 
IBD Disability Index in restorative proctocolectomy
 06 December 2016 
Anti-TNF therapy for IBD
 06 December 2016 
Crohn's disease and thyroid cancer risk
 05 December 2016 
Disease mangement in IBD
 05 December 2016 
New biomarkers for IBD diagnosis
 05 December 2016 
Reducing hospitalization in IBD
 02 December 2016 
Hep E in acute liver failure
 02 December 2016 
Occurrence and severity of alcoholic hepatitis
 02 December 2016 
Food antigen in active eosinophilic esophagitis
 01 December 2016 
Iron deficiency in anemic ulcerative colitis patients
 01 December 2016 
Prognostic factors after paracetamol-induced liver failure
 01 December 2016 
Factors that influence colorectal cancer screening findings
 30 November 2016 
Certolizumab pegol in Crohn's disease
 30 November 2016 
Genetic risk of Crohn's in chronic granulomatous disease
 30 November 2016 
Rifaximin in diarrhea-predominant IBS
 29 November 2016 
Assessing liver steatosis
 29 November 2016 
Treating Zenker's diverticulum
 29 November 2016 
Colorectal cancer surveillance in ulcerative colitis
 28 November 2016 
Complications in celiac disease
 28 November 2016 
Monitoring IBD with mobile technology
 28 November 2016 
Reducing warfarin-related upper GI bleeds
 25 November 2016 
Metal vs plastic stents for pancreatic cancer surgery
 25 November 2016 
Yoga and IBS therapy 
 25 November 2016 
Colorectal cancer screening issues
 24 November 2016 
Partner burden in celiac disease
 24 November 2016 
Fusobacterium nucleatum for colorectal cancer prognosis
 24 November 2016 
PPIS and gastric cancer risk
 23 November 2016 
Diagnosing autoimmune pancreatitis
 23 November 2016 
Readmissions in cirrhosis
 23 November 2016 
Quality assurance standards for colonoscopy
 22 November 2016 
Fatigue in IBD
 22 November 2016 
PPIs and C. diff in ICU 
 22 November 2016 
Bile acid diarrhea in function bowel disorder with diarrhea
 21 November 2016 
Financial incentives and colorectal cancer screening
 21 November 2016 
Pain after endoscopic resection of gastric tumors
 21 November 2016 
Antivirals and chemotherapy in Hep C patients with cancer
 18 November 2016 
Colorectal cancer risk and self-reported family history
 18 November 2016 
Ustekinumab in Crohn’s disease
 18 November 2016 
Antivirals and chemotherapy in Hep C patients with cancer
 17 November 2016 
Risk of overweight in infants
 17 November 2016 
Moderate alcohol consumption and NAFLD
 17 November 2016 
Liver-related specialty care in patients with Hep C
 16 November 2016 
PPI therapy in liver disease
 16 November 2016 
Education in Gastroenterology fellowship
 16 November 2016 
Paternal preconceptional use of anti-TNF-α agents
 15 November 2016 
Novel treatment of NASH 
 15 November 2016 
Physician perspectives on Hep C management
 15 November 2016 
Contraceptives and ulcerative colitis
 14 November 2016 
Cardiovascular risk in NAFLD 
 14 November 2016 
Vit D and NAFLD
 14 November 2016 
Malignancy risk in IBD 
 11 November 2016 
Treatment of Hep C along with opioid agonist therapy
 11 November 2016 
Diabetes and liver cancer risk in Hep C cirrhosis
 11 November 2016 
Biomarker of cirrhosis progression
 10 November 2016 
Testosterone levels and cirrhosis outcomes in men
 10 November 2016 
Improving bowel quality before colonoscopy
 10 November 2016 
Fecal microbiota transplantation and CDI episodes
 09 November 2016 
Minimizing costs of esophagogastroduodenoscopy and colonoscopy
 09 November 2016 
Risk of TB in IBD patients receiving therapy
 09 November 2016 
Liver transplant wait-list and mortality in infants

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2016 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us