Diabetic patients reportedly have a higher incidence of peptic ulcer disease.
Dr Yen-Ling Peng and colleagues from Taiwan investigated if type II diabetic patients have higher risk of developing peptic ulcer bleeding,to identify possible risk factors of peptic ulcer bleeding in diabetic patients.
The doctors analyzed the National Health Insurance Research Database of Taiwan, records of 5699 type II diabetic patients and 11,226 age- and sex-matched non-diabetic patients in a 1:2 ratio were extracted for comparison from a cohort dataset of 1000000 randomly sampled subjects.
Cox proportional hazard regressions were used to evaluate independent risk factors for peptic ulcer bleeding in all patients and identified risk factors of peptic ulcer bleeding in type II diabetic patients.
|Chronic renal disease was a risk factor for peptic ulcer bleeding in diabetic patients|
|Joernal of Gastroenterology and Hepatology|
In a 7-year follow-up period, type II diabetic patients had significantly higher cumulative hazard of peptic ulcer bleeding than the controls.
The researchers observed that diabetes was independently associated with increased risk of peptic ulcer bleeding after adjusting for age, sex, comorbidities, and ulcerogenic medication.
The team noted that age, chronic renal disease, history of peptic ulcer disease, and use of non-steroidal anti-inflammatory drugs were risk factors for peptic ulcer bleeding in diabetic patients.
Dr Peng's team concludes, "Type II diabetic patients have significantly higher risk of peptic ulcer bleeding even after adjustments for possible confounding factors like age, sex, underlying comorbidities, and ulcerogenic medication."