Esophageal dilation is one of the most effective options in the management of symptoms of eosinophilic esophagitis.
However, earlier reports described an increased rate of complications.
Dr Moawad and colleagues from Maryland, USA performed a meta-analysis of population-based studies of the risks associated with dilation, and the clinical efficacy and duration of response to dilation in eosinophilic esophagitis.
Colleagues searched MEDLINE and EMBASE, and performed a systematic search for published articles since 1977 describing cohort or randomized controlled trials of dilation in eosinophilic esophagitis.
Estimates, including 95% confidence interval, were calculated for the occurrence of complications associated with dilations and percentage of patients with symptom improvement following dilation.
|Dilation occurred in 75% of patients|
|Alimentary Pharmacology & Therapeutics|
The search resulted in 232 references, of which 9 studies were included in the final analysis.
The doctors evaluated 860 eosinophilic esophagitis patients, of whom 525 patients underwent at least 1 oesophageal dilation, and a total of 992 dilations.
There were 3 cases of perforation, and 1 hemorrhage.
The researchers identified 6 studies that reported postprocedural chest pain in 2% of cases.
Clinical improvement from dilation occurred in 75% of patients.
Dr Moawad's team concludes, "Dilation in patients with eosinophilic esophagitis is a safe procedure with a low rate of serious complications, and seems to result in at least a short-term improvement of symptoms in the majority of patients."