Coffee consumption is inversely related to the risk of cirrhosis or hepatocellular carcinoma.
However, the protective effect of coffee drinking against the risk of hepatocellular carcinoma was not established in HBV-prevalent region.
Dr Eun Sun Jang and colleagues from Korea elucidated the relationship between lifetime coffee consumption and the risk of hepatocellular carcinoma development under the consideration of replication status of HBV.
A hospital-based case–control study was performed in 1364 subjects.
A total of 258 hepatocellular carcinoma patients, 480 health-check examinees and 626 patients with chronic liver disease other than hepatocellular carcinoma were interviewed on smoking, alcohol and coffee drinking using a standardized questionnaires.
| High lifetime coffee consumption was negatively associated with hepatocellular carcinoma|
HBV e-antigen status and serum HBV DNA levels were measured in patients infected with HBV.
After adjustment for age, gender, obesity, DM, presence of hepatitis virus and lifetime alcohol drinking/smoking, a high lifetime coffee consumption was an independent protective factor against hepatocellular carcinoma, in each analyses using healthy and risky control groups respectively.
However, the high coffee consumption did not affect the hepatocellular carcinoma risk in patients with HBV after adjustment for HBeAg status, serum HBV DNA level and antiviral therapy.
Dr Jang's team concludes, "A high lifetime coffee consumption was negatively associated with a hepatocellular carcinoma development."
"However, this difference of coffee exposure with the hepatocellular carcinoma group was reduced in chronic hepatitis B patients by the dominant role of viral replication."