Help
Subscribe


All of GastroHep is now free access! - Click here to register Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Risk of colorectal high-grade dysplasia and cancer in IBD

A prospective study in the latest issue of Gastroenterology investigates the risk of colorectal high-grade dysplasia and cancer in patients with IBD.

News image

There is an unclear risk of colonic high-grade dysplasia and colorectal cancer among patients with inflammatory bowel disease treated with immunosuppressants.

Dr Laurent Beaugerie and colleagues analyzed data on colorectal cancer development among patients with inflamatory bowel disease enrolled in the observational cohort Cancers et Surrisque Associť aux Maladies Inflammatoires Intestinales En France.

The research team followed and collected data from 19,486 patients with inflamatory bowel disease enrolled in Cancers et Surrisque Associť aux Maladies Inflammatoires Intestinales En France from 2004 to 2005, and followed them until 2007.

When the study began, 2841 patients were characterized as having long-standing extensive colitis.

Early lesions high-grade dysplasia and colorectal cancer were defined as those diagnosed within 10 years after diagnosis of inflammatory bowel disease.

The standardized incidence ratios of colorectal cancer were 2.2 for all IBD patients
Gastroenterology

The researchers evaluated 37 patients that developed colorectal cancer during the follow-up period, and 20 developed colorectal higher-grade dysplasia.

The standardized incidence ratios of colorectal cancer were 2.2 for all inflammatory bowel disease patients, 7.0 for patients with long-standing extensive colitis, and 1.1 for patients without long-standing extensive colitis.

Among patients with long-standing extensive colitis, the multivariate adjusted hazard ratio for colorectal high-grade dysplasia and cancer was 0.28 for those who received thiopurines compared with those who never received thiopurine therapy.

The team observed that 22 patients developed early lesions.

The research team noted that 7 of these were related to inflammatory bowel disease, based on histologic analysis.

Dr Beaugerie's team comments, "Patients with IBD and long-standing extensive colitis are at increased risk for colorectal cancer, although the risk is lower among patients receiving thiopurine therapy."

"Patients without long-standing extensive colitis have a risk for colorectal cancer similar to that of the general population, but they can develop inflammatory bowel disease-related lesions within 10 years after diagnosis of inflamatory bowel disease."

Gastroenterol 2013: 145(1): 166-175
18 July 2013

Go to top of page Email this page Email this page to a colleague

 30 January 2015

Advanced search
 30 January 2015 
HIV-associated NAFLD and primary NAFLD
 30 January 2015 
Narcotic use in children with IBD
 30 January 2015 
Removal of rectal neoplasms
 29 January 2015 
Pyloric compliance in gastroparesis
 29 January 2015 
Gastric cancer in peptic ulcer disease
 29 January 2015 
Genetics and risk of Barrett's
 28 January 2015 
Metabolic syndrome in celiac disease
 28 January 2015 
Remission in Crohn's disease
 28 January 2015 
Surgery and quality of life in rectal cancer
 27 January 2015 
Outcomes for liver transplantation
 27 January 2015 
Psychological distress and fecal composition in IBS
 27 January 2015 
Risk of upper GI cancers in GERD
 26 January 2015 
Breath analysis for IBD
 26 January 2015 
Fecal microbiota transplantation
 26 January 2015 
Antidepressants and GERD
 23 January 2015 
Liver transplant outcomes
 23 January 2015 
Breath analysis in IBD
 23 January 2015 
Fecal microbiota transplantation
 22 January 2015 
NASH and lipid improvements
 22 January 2015 
NAFLD and NASH with psoriasis
 22 January 2015 
Predicting outcomes in HCV-related advanced liver disease
 21 January 2015 
Colon capsule versus CT colonography
 21 January 2015 
Barrett's esophagus screening in the community
 21 January 2015 
Portal vein obstruction
 20 January 2015 
Modulating mucosal damage in Crohn's
 20 January 2015 
Novel techniques for Barrett's screening
 20 January 2015 
Food intolerance
 19 January 2015 
Treatment of fecal incontinence
 19 January 2015 
Hepatic cyst infection
 19 January 2015 
Risk of IBS among relatives
 16 January 2015 
Colorectal cancer screening uptake
 16 January 2015 
NAFLD and NASH in patients with psoriasis
 16 January 2015 
Fecal incontinence
 15 January 2015 
Coffee intake and liver disease
 15 January 2015 
NAFLD in primary care practice
 15 January 2015 
Management of univestigated dyspepsia
 14 January 2015 
Missed colorectal cancers after colonoscopy with polypectomy
 14 January 2015 
Inflixmab response in Crohn's
 14 January 2015 
Statins and liver injury in chronic liver disease
 13 January 2015 
Cytomegalovirus in IBD
 13 January 2015 
Helicobacter-negative gastritis
 13 January 2015 
Hep B vaccine in IBD
 12 January 2015 
Survival in Hep B virus-related hepatocellular carcinoma
 12 January 2015 
Relapse of Crohn's disease after surgery
 12 January 2015 
Late liver metastases of colorectal cancer
 09 January 2015 
Fecal microbiota transplantation for refractory Crohn's
 09 January 2015 
Hypercoagulability after liver resection
 09 January 2015 
Naps and gastroesophageal reflux vs nocturnal sleep
 08 January 2015 
Post-infectious functional dyspepsia
 08 January 2015 
Diagnosis of liver iron overload
 08 January 2015 
Digestive tract damage in Crohn's disease
 07 January 2015 
Early-onset colorectal cancer
 07 January 2015 
SSRIs for noncardiac chest pain
 07 January 2015 
SSRIs and upper GI bleeds
 06 January 2015 
Detection of inflammation in Crohn's
 06 January 2015 
Leptin and early-onset extreme obesity
 06 January 2015 
Goals of IBD treatment
 19 December 2014 
Thiopurine treatment and colectomy in ulcerative colitis
 19 December 2014 
Idiopathic inflammatory demyelinating disease in IBD
 19 December 2014 
Colorectal cancer risk for first-degree relatives

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2015 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us